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Mechanical disturbance of osteoclasts induces atp release that leads to protein synthesis in skeletal muscle through an akt-mtor signaling pathway
(MDPI, 2022)
Muscle and bone are tightly integrated through mechanical and biochemical signals.
Osteoclasts are cells mostly related to pathological bone loss; however, they also start physiological
bone remodeling. Therefore, ...
Sarcoplasmic reticulum and calcium signaling in muscle cells: Homeostasis and disease
(Elsevier, 2020)
The sarco/endoplasmic reticulum is an extensive, dynamic and heterogeneous membranous network that fulfills multiple homeostatic functions. Among them, it compartmentalizes, stores and releases calcium within the intracellular ...
IP3 receptor blockade restores autophagy and mitochondrial function in skeletal muscle fibers of dystrophic mice
(Elsevier B.V., 2018)
© 2018 Duchenne muscular dystrophy (DMD) is characterized by a severe and progressive destruction of muscle fibers associated with altered Ca2+ homeostasis. We have previously shown that the IP3 receptor (IP3R) plays a ...
Influence of mucosal mechanoreceptors on elevator muscle activity in healthy subjects
(1991)
An analysis of saliva swallowing and tonic electromyographic activity was undertaken in 15 healthy subjects with complete natural dentitions with and without a palatal base inserted. Recordings were performed by placing ...
Angiotensin (1-7) decreases myostatin-induced NF-kappa B signaling and skeletal muscle atrophy
(MDPI, 2020)
Myostatin is a myokine that regulates muscle function and mass, producing muscle atrophy. Myostatin induces the degradation of myofibrillar proteins, such as myosin heavy chain or troponin. The main pathway that mediates ...
Changes in gene expression of the MCU complex are induced by electrical stimulation in adult skeletal muscle
(Frontiers Media, 2021)
The slow calcium transient triggered by low-frequency electrical stimulation (ES) in adult muscle fibers and regulated by the extracellular ATP/IP3/IP3R pathway has been related to muscle plasticity. A regulation of muscular ...
Premature loss of muscle mass and function in type 2 diabetes
(Elsevier, 2016)
Introduction: Muscle mass and function are among the most relevant factors that contribute to an optimal quality of life, and are strong predictors of mortality in the elderly. Loss of lean tissues and deterioration of ...
Effects of enalapril or nifedipine on muscle strength or functional capacity in elderly subjects. A double blind trial
(2009)
Introduction. The inhibition of angiotensin-converting enzyme could be useful to avoid sarcopenia in the elderly. Materials and methods. We compared in a prospective double blind trial, the effects of treatment with enalapril ...
Ultrastructural preservation of tissues and their reaction to the infection with trichinella in the El Plomo mummy: muscle fiber ultrastructure and trichinosis/mummy of the Cerro El Plomo
(Wiley, 2017)
The El Plomo mummy was a pre-Columbian Incan child who was found mummified in the Andes Mountains above an altitude of 17,700 feet. In the environment, natural mummification occurred due to low temperatures and strong ...
Membrane depolarization induces calcium-dependent upregulation of Hsp70 and Hmox-1 in skeletal muscle cells
(2009)
Heat shock proteins (HSPs) are a conserved family of cytoprotective polypeptides, synthesized by cells in response to stress. Hsp70 and heme oxygenase 1 (Hmox-1) are induced by a variety of cellular stressors in skeletal ...