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In Vitro maturation of fully grown mouse antral follicles in the presence of 1 nM 2-Hydroxyestradiol improves Oocytes’ developmental competence
(Springer, 2020)
Cathecolestrogens are estradiol metabolites produced during folliculogenesis in the mammalian ovary. 2-Hydroxyestradiol (2-OHE2) is one of the most abundant although its role remains unknown. The aim of this study is to ...
Tubulin and microtubule‐associated protein pools in unfertilized and fertilized eggs of the trout Oncorhynchus mykiss
(1995)
A molecular characterization of tubulin and microtubule‐associated proteins (MAPs) along with their intracellular pool distributions in both unfertilized and fertilized oocytes of the trout Oncorhynchus mykiss was carried ...
Regulation of cytoskeletal dynamics by redox signaling and oxidative stress: implications for neuronal development and trafficking
(Frontiers Media, 2015)
A proper balance between chemical reduction and oxidation (known as redox balance)
is essential for normal cellular physiology. Deregulation in the production of oxidative
species leads to DNA damage, lipid peroxidation ...
The MAP1B case: An old MAP that is new again
(John Wiley, 2014)
The functions of microtubule-associated protein 1B (MAP1B) have historically been linked to the development of the nervous system, based on its very early expression in neurons and glial cells. Moreover, mice in which MAP1B ...
Microtubule proteins and their post-translational forms in the cerebrospinal fluid of patients with paraparesis associated with HTLV-I infection and in SH-SY5Y cells: An in vitro model of HTLV-I-induced disease
(SOC BIOLGIA CHILE, 2008)
HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is characterized by axonal
degeneration of the corticospinal tracts. The specific requirements for transport of proteins and organelles to
the distal ...
Interactome Analysis of Microtubule-targeting Agents Reveals Cytotoxicity Bases in Normal Cells
(2017)
Cancer causes millions of deaths annually and microtubule-targeting agents (MTAs) are the most commonly-used anti-cancer drugs. However, the high toxicity of MTAs on normal cells raises great concern. Due to the non-selectivity ...
Anthraquinone Derivative Reduces Tau Oligomer Progression by Inhibiting Cysteine-Cysteine Interaction
(Wiley-VCH Verlag, 2019)
Tau protein is a natively unfolded protein whose primary role is to participate in axonal transport closely associated with microtubules. Neurodegenerative disorders including Alzheimer's disease and Tauopathies involved ...
Marlin-1 is expressed ion testis and associates to the cytoskeleton and GABA(B) receptors
(WILEY-LISS, DIV JOHN WILEY & SONS INC, 2008-02-15)
Marlin-1 is a GABAB receptor and Jak tyrosine kinase-binding protein that also associates with RNA and
microtubules. In humans and rodents, expression of Marlin-1 is predominantly restricted to the brain, but expression ...
Cytological characterization of the germinal line during testicular differentiation in the lizard Liolaemus gravenhorsti (gray)
(1982)
The gross morphology, histology, and ultrastructure of Liolaemus gravenhorsti gonads prior to and after differntiation are described. Special emphasis has been given to characterization and changes of the germ cell line ...
Topological properties and in vitro identification of essential nodes of the Paclitaxel and Vincristine interactomes in PC-3 cells
(2019)
Background: Microtubule-targeting agents (MTAs) disrupt microtubule dynamics, thereby inducing apoptosis via mitochondrial pathway activation through the modulation in the expression of the Bcl-2 family. Methods: To describe ...