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The effects of hormonal contraceptives on glycemic regulation
(Maney Publishing, 2014)
A number of side effects have been linked to the use of hormonal contraceptives, among others, alterations in glucose levels. Hence, the objective of this mini-review is to show the main effects of hormonal
contraceptive ...
The Drosophila insulin-degrading enzyme restricts growth by modulating the PI3K pathway in a cell-autonomous manner
(2014)
Mammalian insulin-degrading enzyme (IDE) cleaves insulin, among other peptidic
substrates, but its function in insulin signaling is elusive. We use the Drosophila system to define the function of IDE in the regulation of ...
Effect of TNF-α on molecules related to the insulin action in endometrial cells exposed to hyperandrogenic and hyperinsulinic conditions characteristics of polycystic ovary syndrome
(SAGE Publications Inc., 2018)
© The Author(s) 2017. Polycystic ovary syndrome (PCOS) affects not only ovarian functions but is also able to affect endometrium metabolism. Around 80% of women with PCOS are obese. High tumor necrosis factor (TNF)-α ...
The insulin-sensitizing mechanism of myo-inositol is associated with AMPK activation and GLUT-4 expression in human endometrial cells exposed to a PCOS environment
(American Physiological Society, 2020)
Polycystic ovary syndrome (PCOS) is an endocrine-metabolic disorder characterized by hyperandrogenism and ovulatory dysfunction but also obesity and hyperinsulinemia. These characteristics induce an insulin-resistant state ...
Opiate antagonist treatment of ovarian failure
(1993)
One-hundred-and-thirty-eight women suffering from hypothalamicor hyperandrogenic ovarian failure were treatedwith daily doses of 25-150 mg of the opiate antagonist naltrexone for 4-100 weeks.In patients with hypothalamicovarian ...
Intestinal FABP2 A54T polymorphism: Association with insulin resistance and obesity in women
(NORTH AMER ASSOC STUDY OBESITY, 2004-02)
Objective: To assess the association between the Ala54Thr genetic polymorphism of the fatty acid-binding protein 2 (FABP2) gene with insulin resistance and obesity.
Research Methods and Procedures: According to a sampling ...
Is mitochondrial dysfunction a common root of noncommunicable chronic diseases?
(Endocrine Society, 2020)
Mitochondrial damage is implicated as a major contributing factor for a number of noncommunicable chronic diseases such as cardiovascular diseases, cancer, obesity, and insulin resistance/type 2 diabetes. Here, we discuss ...
Protective effect of the hydroalcoholic extract from Lampaya medicinalis Phil. (Verbenaceae) on palmitic acid- impaired insulin signaling in 3T3-L1 adipocytes
(Elsevier, 2020)
Background: Obesity is strongly associated with insulin resistance (IR). IR at the molecular level may bedefined as a diminished activation of insulin signaling-related molecules (IRS-1/Akt/AS160) as well asreduced glucose ...
The cholesterol-lowering agent methyl-β-cyclodextrin promotes glucose uptake via GLUT4 in adult muscle fibers and reduces insulin resistance in obese mice
(American Physiological Society, 2015)
Insulin stimulates glucose uptake in adult skeletal muscle by promoting the translocation of GLUT4 glucose transporters to the transverse tubule (T-tubule) membranes, which have particularly high cholesterol levels. We ...