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Characterization of cellular states of CHO-K1 suspension cell culture through cell cycle and RNA-sequencing profiling
(Elsevier Science, 2018-11)
Chinese hamster ovary (CHO) derived cell lines are the preferred host system for the production of therapeutic proteins. The aim of this work was to explore the regulation of suspension-adapted CHO-K1 host cell line ...
Unconventional pro-inflammatory CD4+ T cell response in B cell-deficient mice infected with Trypanosoma cruzi
(Frontiers Research Foundation, 2017-11-21)
Chagas disease, caused by the parasite Trypanosoma cruzi, is endemic in Latin America but has become a global public health concern by migration of infected people. It has been reported that parasite persistence as well ...
Impact of the Placental Cytokine-Chemokine Balance on Regulation of Cell-Cell Contact-Induced Human Immunodeficiency Virus Type 1 Translocation across a Trophoblastic Barrier In Vitro
(American Society for Microbiology, 2005-10)
Cells constituting the placental barrier secrete soluble factors that may participate in controlling human immunodeficiency virus type 1 (HIV-1) transmission from the mother to the fetus. In this study, we asked whether ...
Probiotic bacteria and their cell walls induce Th1-Type immunity against Salmonella Typhimurium Challenge
(Frontiers Media S.A., 2021-05-12)
Probiotics have been associated with a variety of health benefits. They can act as adjuvant to enhance specific immune response. Bacterial cell wall (CW) molecules are key structures that interact with host receptors ...
Limited Foxp3+ regulatory T cells response during acute Trypanosoma cruzi infection is required to allow the emergence of robust parasite-specific CD8+ T cell immunity
(Frontiers Media S.A., 2018-11)
While it is now acknowledged that CD4+ T cells expressing CD25 and Foxp3 (Treg cells) regulate immune responses and, consequently, influence the pathogenesis of infectious diseases, the regulatory response mediated by Treg ...
Biosensors for studies on adhesion-mediated cellular responses to their microenvironment
(Frontiers Media, 2020-10)
Cells interact with their microenvironment by constantly sensing mechanical and chemical cues converting them into biochemical signals. These processes allow cells to respond and adapt to changes in their environment, and ...
Development of Magoh protein-overexpressing HEK cells for optimized therapeutic protein production
(Journal of the Serbian Chemical Society, 2020-04)
In the pharmaceutical industry, the need for high levels of protein expression in mammalian cells has prompted the search for new strategies, including technologies to obtain cells with improved mechanisms that enhance its ...
Potato Snakin-1 Gene Silencing Affects Cell Division, Primary Metabolism, and Cell Wall Composition
(American Society of Plant Biologists, 2012-01)
Snakin-1 (SN1) is an antimicrobial cysteine-rich peptide isolated from potato (Solanum tuberosum) that was classified as a member of the Snakin/Gibberellic Acid Stimulated in Arabidopsis protein family. In this work, a ...
Impedance spectroscopy applied to the fast wounding dynamics of an electrical wound-healing assay in mammalian cells
(IOP Publishing, 2015-06-25)
Electrical wound-healing assays are often used as a means to study in vitro cell migration and proliferation. In such analysis, a cell monolayer that sits on a small electrode is electrically wounded and its spectral ...