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The application of probiotics in cancer
(Cambridge University Press, 2007-10)
Lactic acid bacteria (LAB) are present in many foods such as yoghurt and are frequently used as probiotics to favour some biological functions in the host. Many investigators have evaluated the therapeutic effects of yoghurt ...
Metformin and propranolol combination prevents cancer progression and metastasis in different breast cancer models
(Impact Journals LLC, 2017-01)
Discovery of new drugs for cancer treatment is an expensive and time-consuming process and the percentage of drugs reaching the clinic remains quite low. Drug repositioning refers to the identification and development of ...
Hyaluronan metabolism is associated with DNA repair genes in breast and colorectal cancer: Screening of potential progression markers using qPCR
(MDPI AG, 2020-06-29)
In this work, we compared mRNA levels of Hyaluronan (HA) metabolism members and BRCA genes, known to be involved in the tumoral process, between tumor and non-tumor adjacent tissue and its correlation with previously ...
Milk fermented by Lactobacillus casei CRL431 administered as an immune adjuvant in models of breast cancer and metastasis under chemotherapy
(Springer, 2021-01)
Chemotherapy is the most common treatment for breast cancer and its metastasis; however, it affects the patients' quality of life. Previously, it was demonstrated that milk fermented by Lactobacillus casei CRL431 (probiotic ...
Targeting FGFR with BGJ398 in breast cancer: Effect on tumor growth and metastasis
(Bentham Science Publishers, 2017-12)
AbstractBACKGROUND:Endocrine resistance and metastatic dissemination comprise major clinical challenges for breast cancer treatment. The fibroblast growth factor receptor family (FGFR) consists of four tyrosine kinase ...
Impact of endocrine disruptor hexachlorobenzene on the mammary gland and breast cancer: The story thus far
(Academic Press Inc Elsevier Science, 2019-06)
Breast cancer incidence is increasing globally and exposure to endocrine disruptors has gained importance as a potential risk factor. Hexachlorobenzene (HCB) was once used as a fungicide and, despite being banned, considerable ...
Retinoic acid reduces migration of human breast cancer cells: role of retinoic acid receptor beta
(Wiley, 2014-01)
Breast cancer is the most common malignancy in women and the appearance of distant metastases produces the death in 98% of cases. The retinoic acid receptor b (RARb) is not expressed in 50% of invasive breast carcinoma ...
Clinical and therapeutic relevance of the metabolic oncogene fatty acid synthase in HER2+ breast cancer
(Universidad de Murcia, 2017-07)
Fatty acid synthase (FASN) is a key lipogenic enzyme for de novo fatty acid biosynthesis and a druggable metabolic oncoprotein that is activated in most human cancers. We evaluated whether the HER2-driven lipogenic phenotype ...
Microenvironment and endocrine resistance in breast cancer: Friend or foe?
(Baishideng Publishing Group, 2015-12)
Breast cancer affects one in eight women around the world. Seventy five percent of these patients have tumors that are estrogen receptor positive and as a consequence receive endocrine therapy. However, about one third ...
Anticancer and Antimetastatic Activity of Copper(II)-tropolone complex against human breast cancer cells, breast multicellular spheroids and mammospheres
(Elsevier Science Inc, 2020-03)
The goal of this work was to display the anticancer and antimetastatic activity of a copper(II) with tropolone (trp), complex [Cu(trp)2] toward human breast cancer cells in monolayer (2D) and spheroids (3D). Cytotoxicity ...