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Mostrando ítems 11-20 de 461
Antiprogestins in breast cancer treatment: Are we ready?
(BioScientifica, 2012-06)
Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death in females worldwide. It is accepted that breast cancer is not a single disease, but instead constitutes a spectrum of tumor ...
Asymmetric cancer hallmarks in breast tumors on different sides of the body
(Public Library of Science, 2016-07)
During the last decades it has been established that breast cancer arises through the accumulation of genetic and epigenetic alterations in different cancer related genes. These alterations confer the tumor oncogenic ...
Cancer stem cells: Culprits in endocrine resistance and racial disparities in breast cancer outcomes
(Elsevier Ireland, 2021-03)
Breast cancer stem cells (BCSCs) promote endocrine therapy (ET) resistance, also known as endocrine resistance in hormone receptor (HR) positive breast cancer. Endocrine resistance occurs via mechanisms that are not yet ...
Tumor necrosis factor alpha blockade: an opportunity to tackle breast cancer
(Frontiers Media S.A., 2020-06)
Breast cancer is the most frequently diagnosed cancer and the principal cause of mortality by malignancy in women and represents a main problem for public health worldwide. Tumor necrosis factor α (TNFα) is a pro-inflammatory ...
Learning deep features for dead and living breast cancer cell classification without staining
(Springer Nature, 2021-05)
Automated cell classification in cancer biology is a challenging topic in computer vision and machine learning research. Breast cancer is the most common malignancy in women that usually involves phenotypically diverse ...
Preclinical efficacy of CIGB-300, an anti-CK2 peptide, on breast cancer metastasic colonization
(Nature, 2020-09-07)
CK2 is a serine/threonine kinase that is overexpressed in breast cancer and its inhibition is associated to reduced tumor growth and disease progression. CIGB-300 is an antitumor peptide with a novel mechanism of action, ...
Study of the Genetic Variants in BRCA1/2 and Non-BRCA Genes in a Population-Based Cohort of 2155 Breast/Ovary Cancer Patients, Including 443 Triple-Negative Breast Cancer Patients, in Argentina
(MDPI, 2021-05-31)
Gene/s sequencing in hereditary breast/ovary cancer (HBOC) in routine diagnosis is challenged by the analysis of panels. We aim to report a retrospective analysis of BRCA1/2 and non-BRCA gene sequencing in patients with ...
Tumor-associated macrophages induce endocrine therapy resistance in ER+ breast cancer cells
(MDPI AG, 2019-02)
Antiestrogenic adjuvant treatments are first-line therapies in patients with breast cancer positive for estrogen receptor (ER+). Improvement of their treatment strategies is needed because most patients eventually acquire ...
Human breast adipose tissue: characterization of factors that change during tumor progression in human breast cancer
(BioMed Central, 2017-02-07)
Adipose microenvironment is involved in signaling pathways that influence breast cancer. We aim to characterize factors that are modified: 1) in tumor and non tumor human breast epithelial cell lines when incubated with ...