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Mutational effects on the clonal interference phenomenon
(Soc Study EvolutionLawrenceEUA, 2004)
Dynamics of fixation of advantageous mutations
(Elsevier Science BvAmsterdamHolanda, 2004)
Fixation of beneficial mutations in the presence of epistatic interactions
(Academic Press Ltd Elsevier Science LtdLondonInglaterra, 2004)
beta-glucans in promoting health: Prevention against mutation and cancer
(Elsevier B.V., 2008-03-01)
The polysaccharides beta-glucans occur as a principal component of the cellular walls. Some microorganisms, such as yeast and mushrooms, and also cereals such as oats and barley, are of economic interest because they contain ...
Dasatinib Overrides Imatinib Resistance Mediated by the F359I Residue Mutation in Two Patients with Chronic Myeloid Leukemia
(KARGERBASEL, 2012)
Despite the beneficial effects of imatinib mesylate, some patients may either not respond or respond suboptimally. Here, we report two chronic myelogenous leukemia patients; one had a suboptimal response according to ...
Cytotoxicity and genotoxicity of Agaricus blazei methanolic extract fractions assessed using gene and chromosomal mutation assays
(Sociedade Brasileira de Genética, 2008-01-01)
Functional food investigations have demonstrated the presence of substances that could be beneficial to human health when consumed. However, the toxic effects of some substances contained in foods have been determined. ...
Improving the thermostability of xylanase a from bacillus subtilis by combining bioinformatics and electrostatic interactions optimization
(2021-05-06)
The rational improvement of the enzyme catalytic activity is one of the most significant challenges in biotechnology. Most conventional strategies used to engineer enzymes involve selecting mutations to increase their ...
Investigation of ancestral alleles in the Bovinae subfamily
(2021-12-01)
Background: In evolutionary theory, divergence and speciation can arise from long periods of reproductive isolation, genetic mutation, selection and environmental adaptation. After divergence, alleles can either persist ...
Extracellular matrix-specific Caveolin-1 phosphorylation on tyrosine 14 is linked to augmented melanoma metastasis but not tumorigenesis
(Impact Journals LLC, 2016)
Caveolin-1 (CAV1) is a scaffolding protein that plays a dual role in cancer. In advanced stages of this disease, CAV1 expression in tumor cells is associated with enhanced metastatic potential, while, at earlier stages, ...