Buscar
Mostrando ítems 21-30 de 98
Ancestral-sequence reconstruction unveils the structural basis of function in mammalian FMOs
(Nature, 2020-01)
Flavin-containing monooxygenases (FMOs) are ubiquitous in all domains of life and metabolize a myriad of xenobiotics, including toxins, pesticides and drugs. However, despite their pharmacological importance, structural ...
Crystallographic characterization of the ribosomal binding site and molecular mechanism of action of Hygromycin A.
(Oxford University Press, 2015-11-16)
Hygromycin A (HygA) binds to the large ribosomal subunit and inhibits its peptidyl transferase (PT) activity. The presented structural and biochemical data indicate that HygA does not interfere with the initial binding of ...
Triosephosphate isomerase deficiency: effect of F240L mutation on enzyme structure
(Elsevier Science Inc., 2020-08-15)
Eleven missense mutations have been describe in human triosephosphate isomerase (TPI), affecting its catalytic function. Several of these mutations generate triosephosphate isomerase deficiency, the consequences of which ...
Centennial of X-ray diffraction: development of an unpromising experiment with a wrong explanation
(Taylor & Francis Ltd, 2016-07)
In February 1912 in Munich, P. P Ewald, one of A. Sommerfeld's Ph.D. students, consulted M. Laue on matters related to crystal optics, his thesis subject. During the conversation, Laue conceived the idea that a crystal ...
Structural analysis of methyl 6-O-benzyl-2-deoxy-2-dimethylmaleimido- α-D-allopyranoside by X-ray crystallography, NMR, and QM calculations: Hydrogen bonding and comparison of density functionals
(Elsevier, 2012-05)
The crystal structure of methyl 6-O-benzyl-2-deoxy-2-dimethylmaleimido- α-d-allopyranoside was solved in order to gain insight into the hydrogen bond features which can be determining features in the glycosylation ...
Crystal structures of peanut lectin in the presence of synthetic β-N- And β-S-galactosides disclose evidence for the recognition of different glycomimetic ligands
(International Union of Crystallography, 2020-11)
Carbohydrate-lectin interactions are involved in important cellular recognition processes, including viral and bacterial infections, inflammation and tumor metastasis. Hence, structural studies of lectin-synthetic glycan ...
Texture and Stress: the forgotten X-ray Diffraction applications applied to materialsTextura y Estrés: las aplicaciones olvidadas de la Difracción de Rayos X en materiales
(Pontificia Universidad Católica del Perú, 2020)
Kinetic and structural studies of aldehyde oxidoreductase from Desulfovibrio gigas reveal a dithiolene-based chemistry for enzyme activation and inhibition by H2O2
(Public Library of Science, 2013-12-31)
Mononuclear Mo-containing enzymes of the xanthine oxidase (XO) family catalyze the oxidative hydroxylation of aldehydes and heterocyclic compounds. The molybdenum active site shows a distorted square-pyramidal geometry in ...
Structures of type B ribose 5‐phosphate isomerase from Trypanosoma cruzi shed light on the determinants of sugar specificity in the structural family
(Wiley Blackwell Publishing, Inc, 2011-03)
Ribose‐5‐phosphate isomerase (Rpi; EC 5.3.1.6) is a key activity of the pentose phosphate pathway. Two unrelated types of sequence/structure possess this activity: type A Rpi (present in most organisms) and type B Rpi ...
Antibody-based inhibition of pathogenic new world hemorrhagic fever mammarenaviruses by steric occlusion of the human transferrin receptor 1 apical domain
(American Society for Microbiology, 2021-09)
Pathogenic clade B New World mammarenaviruses (NWM) can cause Argentine, Venezuelan, Brazilian, and Bolivian hemorrhagic fevers. Sequence variability among NWM glycoproteins (GP) poses a challenge to the development of ...