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Progesterone loaded thermosensitive hydrogel for vaginal application: Formulation and in vitro comparison with commercial product
(Elsevier B.V., 2019-09)
Progesterone (PGT) is a natural hormone that stimulates and regulates various important functions, such as the preparation of the female body for conception and pregnancy. Due to its low water solubility, it is administered ...
Physicochemical characterization of 2-hydroxybenzophenone with β-cyclodextrin in solution and solid state
(American Chemical Society, 2015-05)
The characterization of the inclusion complex between 2-hydroxybenzophenone (2OHBP) and β-cyclodextrin (βCD) in the solid state was performed using Fourier transform infrared spectroscopy (FTIR), powder X-ray diffractometry ...
Development and characterization of benznidazole nano- and microparticles: A new tool for pediatric treatment of Chagas disease?
(Elsevier Science, 2019-01)
Benznidazole (BNZ) is the drug of choice for the treatment of Chagas disease in many countries. However, its low water solubility produces low and/or variable oral bioavailability. Thus, the aim of this work was to formulate ...
Efficacy of novel benznidazole solutions during the experimental infection with Trypanosoma cruzi
(Elsevier Ireland, 2013-02)
Chagas' disease is caused by the protozoan parasite Trypanosoma cruzi. About 8. million people throughout Latin America are infected causing approximately 10,000 deaths annually. Benznidazole, available as unique 100. mg ...
Binary systems of albendazole desmotropes with amino-acids: Experimental and theoretical studies
(Elsevier Science, 2021-10-15)
In this work, new binary systems of albendazole desmotropes with amino-acids were developed and investigated. In particular, solubility studies evidenced that aspartic acid and glutamic acid were the most important enhancer ...
Behavior of ionophore antibiotics in aquatic environments in Argentina: The distribution on different scales in water courses and the role of wetlands in depuration
(Pergamon-Elsevier Science Ltd, 2019-12)
We studied for the first time three ionophore anticoccidial drugs: monensin (MON), lasalocid (LAS), and salinomycin (SAL) as emerging pollutants originating from animal and plant husbandry in surface waters (n = 89) in one ...
Dendrímeros como nanotransportadores de drogas y como drogas per seDendrimer as drug-nanotransporters and as drug per se
(Universidad Nacional de Quilmes. Secretaría de Posgrado, 2020-05)
En este trabajo se revisan las características y aplicaciones de los dendrímeros. Estos son polímeros tridimensionales con características únicas en el campo de los nanomateriales, que incluyen: arquitectura simétrica, ...
Comparative study of transdermal drug delivery systems of resveratrol: High efficiency of deformable liposomes
(Elsevier Science, 2018-09)
Trans-resveratrol (3, 5, 4′ trihydroxystilbene, RSV) is a natural compound that shows antioxidant, cardioprotective, anti-inflammatory and anticancer properties. The transdermal, painless application of RSV is an attractive ...
Nanodelivery of the Gramicidin Peptide for Enhancing Antimicrobial Activity
(Wiley VCH Verlag, 2021-08)
Gramicidin S (GraS) is an amphiphilic peptide that has emerged as an effective alternative antibiotic. However, its applicability is restricted for clinical uses due to its effect on eukaryotic cells and low aqueous ...
The Structural Biology of Galectin-Ligand Recognition: Current Advances in Modeling Tools, Protein Engineering, and Inhibitor Design
(Frontiers Media S.A., 2019-12)
Galectins (formerly known as “S-type lectins”) are a subfamily of soluble proteins that typically bind β-galactoside carbohydrates with high specificity. They are present in many forms of life, from nematodes and fungi to ...