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Development of self-microemulsifying lipid-based formulations of trans-resveratrol by systematically constructing lipid-surfactant-water phase diagrams using long-chain lipids
(Taylor & Francis, 2021-07)
The aim of this work was to develop self-microemulsifying lipid-based formulations of trans-resveratrol in cod liver oil, a long chain lipid, to increase its solubility, dissolution rate and oral bioavailability. Ternary ...
Structural Elucidation of Poloxamer 237 and Poloxamer 237/Praziquantel Solid Dispersions: Impact of Poly(Vinylpyrrolidone) over Drug Recrystallization and Dissolution
(Springer, 2018-04)
Praziquantel (PZQ) is the recommended, effective, and safe treatment against all forms of schistosomiasis. Solid dispersions (SDs) in water-soluble polymers have been reported to increase solubility and bioavailability of ...
Transtegumental diffusion of benzimidazole anthelmintics into Moniezia benedeni: correlation with their octanol–water partition coefficients
(Academic Press Inc Elsevier Science, 2003-01)
The experiments described here report on the correlation between the ex vivo diffusion of different benzimidazole (BZD) anthelmintics into the cestode parasite Moniezia benedeni, and their octanol–water partition coefficients ...
Albendazole solid dispersions against alveolar echinococcosis: a pharmacotechnical strategy to improve the efficacy of the drug
(Cambridge University Press, 2020-04)
Alveolar echinococcosis is a neglected parasitic zoonosis caused by Echinococcus multilocularis. The pharmacological treatment is based on albendazole (ABZ). However, the low water solubility of the drug produces a limited ...
Effects of the antiparasitic drug moxidectin in cattle dung on zooplankton and benthic invertebrates and its accumulation in a water–sediment system
(Springer, 2018-05)
Two anthelmintic macrocyclic lactones—ivermectin and moxidectin—have revolutionized parasite control in cattle. These drugs are only partly metabolized by livestock, and the main route of excretion is via feces. In seasonally ...
Aplicación del Modelo de Jouyban-Acree para la Estimación de la Solubilidad del Naproxeno en Mezclas Cosolventes Etanol + AguaApplication of the Jouyban-Acree model for Estimating the Solubility of Naproxen in Ethanol + Water Cosolvent Mixtures
(Colegio de Farmacéuticos de la Provincia de Buenos Aires, 2008-12)
En este trabajo se evaluó la validez de una adaptación puntual del modelo de Jouyban-Acree (J-A) en comparación con la utilidad de la ecuación de solubilidad logarítmica-lineal propuesta por Yalkowsky y Roseman (Y-R), para ...
Drug complexation and physicochemical properties of vinylpyrrolidone-N, N′-dimethylacrylamide copolymers
(John Wiley & Sons Inc, 2004-08)
Solid dispersions of the nonsteriodal antiin-flammatory drug (NSAID) 2′,4′-difluoro-4-hydroxy-(1,1′-biphenyl)-3-carboxylic acid (DIF) with the water-soluble random copolymer poly(N-vinyl-2-pyrrolidone-co-N, N′-dimethylacrylamide) ...
Self-assembled micelles of the (lipo) glycopeptides, teicoplanin, as taxane nanocarriers
(IOP Publishing, 2021-11)
The use of nanoparticles is one of the strategies currently studied to minimize the toxicity and lack of tissue specificity of many cancer drugs used in chemotherapy. In this research the physicochemical and biological ...
Novel carvedilol paediatric nanomicelle formulation:in-vitro characterization and in-vivo evaluation
(Pharmaceutical Press-Royal Pharmaceutical Society Great Britian, 2017-06)
Objectives Carvedilol (CAR) is a poorly water-soluble beta-blocker. Its encapsu-lation within nanomicelles (NMs) could improve drug solubility and its oralbioavailability, allowing the development of a paediatric liquid ...
Improving properties of albendazole desmotropes by supramolecular systems with maltodextrin and glutamic acid
(Springer, 2018-04-02)
Albendazole, an effective broad-spectrum anthelmintic agent, showed unpredictable therapeutic response caused by poor water solubility and slow dissolution rate. Then, novel binary and multicomponent supramolecular systems ...