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A highly conserved iron-sulfur cluster assembly machinery between humans and amoeba dictyostelium discoideum: The characterization of frataxin
(Molecular Diversity Preservation International, 2020-09)
Several biological activities depend on iron–sulfur clusters ([Fe-S]). Even though they are well-known in several organisms their function and metabolic pathway were poorly understood in the majority of the organisms. We ...
2-Mercaptomethyl Thiazolidines (MMTZs) Inhibit All Metallo-β-Lactamase Classes by Maintaining a Conserved Binding Mode
(American Chemical Society, 2021-09-06)
Metallo-β-lactamase (MBL) production in Gram-negative bacteria is an important contributor to β-lactam antibiotic resistance. Combining β-lactams with β-lactamase inhibitors (BLIs) is a validated route to overcoming ...
Computational and in vitro Pharmacodynamics Characterization of 1A-116 Rac1 Inhibitor: Relevance of Trp56 in Its Biological Activity
(Frontiers Media, 2020-04-15)
In the last years, the development of new drugs in oncology has evolved notably. In particular, drug development has shifted from empirical screening of active cytotoxic compounds to molecularly targeted drugs blocking ...
Metabolic and physiologic profile during the fruit ripening of three blueberries highbush (Vaccinium corymbosum) cultivars
(IOS Press, 2018-08)
BACKGROUND: Blueberry was introduced as a crop in Argentina about 30 years ago. Its harvesting period ranges from September to December, during the northern hemisphere (its main export destination) fall season, which makes ...
Structural and Functional Comparison of SARS-CoV-2-Spike Receptor Binding Domain Produced in Pichia pastoris and Mammalian Cells
(Cold Spring Harbor Laboratory Press, 2020-09)
The yeast Pichia pastoris is a cost-effective and easily scalable system for recombinant protein production. In this work we compared the conformation of the receptor binding domain (RBD) from SARS-CoV-2 Spike protein ...
Genome-based reclassification of Azospirillum brasilense Az39 as the type strain of Azospirillum argentinense sp. nov.
(Microbiology Society, 2022-08-01)
Strain Az39T of Azospirillum is a diazotrophic plant growth-promoting bacterium isolated in 1982 from the roots of wheat plants growing in Marcos Juárez, Córdoba, Argentina. It produces indole-3- acetic acid in the presence ...
Photodynamic properties and photoinactivation of microorganisms mediated by 5,10,15,20-tetrakis(4-carboxyphenyl)porphyrin covalently linked to silica-coated magnetite nanoparticles
(Elsevier Science Sa, 2017-09)
Magnetic nanoparticles of Fe3O4 (MNP) were synthesized by co-precipitating Fe2+ and Fe3+ ions in an ammonia solution. This MNP was coated with silica using sodium metasilicate to obtain silica-coated MNP (MNPSi). Grafting ...
Reactions of excited states of phenoxazin-3-one dyes with amino acids
(Wiley Blackwell Publishing, Inc, 2005)
Functional Characterization of a LOV-Histidine Kinase Photoreceptor from Xanthomonas citri subsp. citri
(Wiley Blackwell Publishing, Inc, 2015)