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Thrombin-like activity in snake venoms from Peruvian Bothrops and Lachesis genera
(Elsevier, 1991)
Venoms from Lachesis muta muta, Bothrops pictus, B. barnetti, B. atrox and B. hyoprorus coagulate in vitro canine fibrinogen, and both bovine fibrinogen and bovine plasma. B. barnetti and L. muta muta venoms have greater ...
Purification and characterization of jararassin-I, a thrombin-like enzyme from Bothrops jararaca snake venom
(Shanghai Inst Biochemistry, Academia Sinica, 2004-12-01)
A thrombin-like serine protease, jararassin-I, was isolated from the venom of Bothrops jararaca. The protein was obtained in high yield and purity by a single chromatographic step using the affinity resin Benzamidine-Sepharose ...
Structural and thermodynamic analysis of thrombin:suramin interaction in solution and crystal phases
(ELSEVIER SCIENCE BV, 2009)
Suramin is a hexasulfonated naphthylurea which has been recently characterized as a non-competitive inhibitor of human alpha-thrombin activity over fibrinogen, although its binding site and mode of interaction with the ...
Thrombomodulin is required for the antithrombotic activity of thrombin mutant W215A/E217A in a mouse model of arterial thrombosis
(Pergamon-Elsevier Science LtdOxford, 2012)
Structures of the noncovalent complexes of human and bovine prothrombin fragment 2 with human PPACK-thrombin
(1993-12-01)
Both human and bovine prothrombin fragment 2 (the second kringle) have been cocrystallized separately with human PPACK (D-Phe-Pro-Arg)-thrombin, and the structures of these noncovalent complexes have been determined and ...
Structure of thrombin complexed with selective non-electrophilic inhibitors having cyclohexyl moieties at P1
(2000-03-25)
The crystal structures of five new non-electrophilic β-strand-templated thrombin active-site inhibitors have been determined bound to the enzyme. Four co-crystallize with hirugen and inhibitor isomorphously to produce ...
Thrombin Generation Assay and Hemostatic Profile for Elucidating Hypercoagulability in Endogenous Canine Hyperadrenocorticism
(2021-11-01)
Canine hyperadrenocorticism is a common endocrine disorder caused by chronic secretion of glucocorticoid, often associated with hypercoagulability and secondary thrombosis. The thrombin generation assay (TGA) evaluates ...
Molecular characterization of BjussuSP-I, a new thrombin-like enzyme with procoagulant and kallikrein-like activity isolated from Bothrops jararacussu snake venom
(Elsevier France-editions Scientifiques Medicales Elsevier, 2008-03-01)
A thrombin-like enzyme, named BjussuSP-I, isolated from Bothrops jararacussu snake venom, is an acidic single-chain glycoprotein with M-r = 61,000, pI similar to 3.8 and 6% sugar. BjussuSP-I shows high proteolytic activity ...
Myristoylated alanine-rich C kinase substrate phosphorylation is involved in thrombin-induced serotonin release from platelets
(Wiley, 2001-12)
Stimulation of platelets by thrombin induces protein kinase C (PKC) activation, phosphorylation of pleckstrin, aggregation and serotonin release. Here, we demonstrate that, in human platelets, thrombin stimulation also ...