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Wnt-5aoccludes Aβ oligomer-induced depression of glutamatergic transmission in hippocampal neurons
(2010)
Abstract
Background
Soluble amyloid-β (Aβ;) oligomers have been recognized to be early and key intermediates in Alzheimer's disease (AD)-related synaptic dysfunction. Aβ ...
Effect of Alcohol on Hippocampal-Dependent Plasticity and Behavior : Role of Glutamatergic Synaptic Transmission
(2020-01-24)
Problematic alcohol drinking and alcohol dependence are an increasing health problem worldwide. Alcohol abuse is responsible for approximately 5% of the total deaths in the world, but addictive consumption of it has a ...
Age-Dependent Behavioral and Synaptic Dysfunction Impairment Are Improved with Long-Term Andrographolide Administration in Long-Lived Female Degus (Octodon degus)
(2023-01)
In Octodon degus, the aging process is not equivalent between sexes and worsens for females. To determine the beginning of detrimental features in females and the ways in which to improve them, we compared adult females ...
Neuronal surface P antigen (NSPA) modulates postsynaptic NMDAR stability through ubiquitination of tyrosine phosphatase PTPMEG
(2020)
Abstract
Background
Cognitive dysfunction (CD) is common among patients with the autoimmune disease systemic lupus erythematosus (SLE). Anti-ribosomal P autoantibodies ...
Hormetic-like effects of l-homocysteine on synaptic structure, function, and Aβ aggregation
(2020-02)
Alzheimer’s Disease (AD) is the primary cause of dementia among the elderly population. Elevated plasma levels of homocysteine (HCy), an amino acid derived from methionine metabolism, are considered a risk factor and ...
The impact of aged microglia on d-serine-regulated glutamatergic transmission
(Elsevier, 2021-01-01)
Microglia serve a pivotal role in the regulation of the brain environment in neuroinflammation. Their activation depends on highly regulated mechanisms involving various ligands, and pro- and antiinflammatory cytokines. ...
Antibodies and the brain : Antiribosomal P protein antibody and the clinical effects in patients with systemic lupus erythematosus
(2018-06-01)
Purpose of review Analysis of antiribosomal P protein autoantibodies (anti-P) pathogenicity in diffuse brain manifestations of neuropsychiatric lupus, emphasizing cognitive dysfunction and the recently emerged role of ...