Buscar
Mostrando ítems 1-10 de 12
CFRT is involved in colorectal cancer stem cell phenotype
(Fundación Revista Medicina, 2019)
CFTR is a chloride channel expressed in many epithelial cells and there is a relationship between this channel and cancer. The cancer stem cells (CSC) are responsible of tumorigenesis, secondary focus formation in metastasis ...
Evidences pointing that bone marrow originating tumor cells with lung-colonizyng ability, rather than tumor cells remaining within the bone marrow, are related to a mesenchymal stem cell phenotype
(Fundación Revista Medicina, 2019)
A critical challenge in the clinical management of osteosarcoma (OS) is the appearance of lung metastasis. This bone marrow ? associated tumor represents the most frequent bone tumor in pediatrics and young adult populations. ...
Mom is that you? Proteomic approach to assess the relationship between mesenchymal stem cells and Ewing´s sarcoma cells: tracking the cell of origin
(Fundación Revista Medicina, 2020)
Ewing's sarcoma (ES) is a primitive neuroectodermal tumor that mostly affects children and young adults between 5 and 30 years. Understanding the biology and mechanisms involved in ES growth and progression may lead to the ...
Stem: associated features in tumor cells able to colonize secondary tumor sites
(Fundación Medicina Buenos Aires, 2019)
Osteosarcoma (OS), the most frequent bone tumor in pediatrics, presents critical clinical challenges in lung metastasis and chemoresistance emergence. Understanding OS switch into a metastatic phenotype and the interaction ...
Proteomic and bioinformatic approach relates bone marrow-originated tumor cells with lungcolonizing ability, rather than bone marrowresiding tumor cells, to a bone marrow mesenchymal stem cell phenotype
(Sociedad Argentina de Bioingeniería, 2020)
A challenge in osteosarcoma (OS) is lung metastasis occurrence. OS, a bone marrow (BM)–associated tumor, is the most frequent pediatric bone tumor. A large percentage of patients diagnosed without metastasis would already ...
A deficitary model of CDK5 does not impairs neuronal differentiation of human pluripotent stem cells
(Medicina, 2021)
CDK5/P35 is a complex involved in neuronal homeostasis and de- velopment that was described as a critical player for neuronal surviv- al. Besides, its deregulation is linked with neurodegenerative pathol- ogies such as ...
Low Oct4 expression in mesenchymal stem cells contributes to the development of the bone marrow pre-metastatic niche in advanced breast cancer patients
(Fundación Revista Medicina, 2021)
The imbalance between osteogenesis and osteoclastogenesis in the bone marrow (BM) microenvironment seems to play an essential role in the establishment of bone metastasis in untreated advanced breast cancer patients (BCP). ...
Site Specific Knock-In Genome Editing in Human HSCs Using Baboon Envelope gp Pseudotypedviral Derived “Nanoblades” Loaded with Cas9/sgRNA Combined with Donor Encoding AAV-6
(Elsevier, 2019)
Programmable nucleases have enabled rapid and accessible genome engineering in eukaryotic cells and living organisms. Here, we have designed ?Nanoblades?, a new technology that will deliver a genomic cleaving agent into ...
Antioxidant and anti-inflammatory properties of an ethanolic extract of Nectandra angustifolia "Yellow Laurel”
(Fundación Revista Medicina, 2019)
Nectandra angustifolia (N.a.) is a native plant whose leaf and bark extracts have been used in ethnomedicine for the treatment of rheumatism, arthritis, chronic pain and as an antivenom in snakebites. Therefore, the objective ...
Zika virus RNA structures act cooperatively to regulate the production of viral non-coding RNAs with different impact in mosquito and human hosts
(American Society of Virology, 2020)
The explosive epidemic of Zika virus (ZIKV), together with the unique properties of this virus regarding transmission and disease, posed a tremendous challenge to understand the molecular processes that lead to infection ...