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Selective effect of INGAP-PP upon mouse embryonic stem cell differentiation toward islet cells
(Elsevier Science, 2009-02)
We evaluated the effect of islet neogenesis-associated protein pentadecapeptide (INGAP-PP) upon islet β- and non-β cell differentiation from mouse embryonic stem (mES) cells. ES-D3 cell lines were cultured following ...
Insights into Stem Cell Factor chemotactic guidance of neural crest cells revealed by a real-time directionality-based assay
(Elsevier Gmbh, 2012-05)
The extracellular environment through which neural crest cells (NCCs) translocate and differentiate plays a crucial role in the determination of cell migration and homing. In the trunk, NCC-derived melanocyte precursor ...
Stem lodging in sunflower: Variations in stem failure moment of force and structure across crop population densities and post-anthesis developmental stages in two genotypes of contrasting susceptibility to lodging
(Elsevier Science, 2010-03)
Stem lodging is a risk to sunflower production in Argentina, and may contribute to fixing the upper limit to commercially viable crop population density, since yield is known to increase up to densities higher than those ...
Cell cycle dynamics of mouse embryonic stem cells in the ground state and during transition to formative pluripotency
(Nature Publishing Group, 2019-05)
Mouse embryonic stem cells (mESCs) can be maintained as homogeneous populations in the ground state of pluripotency. Release from this state in minimal conditions allows to obtain cells that resemble those of the early ...
Mesenchymal stromal cells in ischemic brain injury
(MDPI, 2022-03-01)
Ischemic brain injury represents a major cause of death worldwide with limited treatment options with a narrow therapeutic window. Accordingly, novel treatments that extend the treatment from the early neuroprotective stage ...
Improving the Therapeutic Ability of Mesenchymal Stem/Stromal Cells for the Treatment of Conditions Influenced by Immune Cells
(Hindawi Publishing Corporation, 2019-12)
Mesenchymal stem/stromal cells (MSCs) have been initially described decades ago as fibroblastic precursors that could be isolated from the bone marrow and establish cultures of fibroblastic cells. These fibroblastic cells ...
Hematopoietic Stem Cells but Not Multipotent Progenitors Drive Erythropoiesis during Chronic Erythroid Stress in EPO Transgenic Mice
(Elsevier, 2018)
The hematopoietic stem cell (HSC) compartment consists of a small pool of cells capable of replenishing all blood cells. Although it is established that the hematopoietic system is assembled as a hierarchical organization ...
Signaling-Dependent Control of Apical Membrane Size and Self-Renewal in Rosette-Stage Human Neuroepithelial Stem Cells
(Cell Press, 2018-06)
In the developing nervous system, neural stem cells are polarized and maintain an apical domain facing a central lumen. The presence of apical membrane is thought to have a profound influence on maintaining the stem cell ...
Proteoglycans and glycosaminoglycans as regulators of cancer stem cell function and therapeutic resistance
(Wiley Blackwell Publishing, Inc, 2019-06-23)
In contrast to the bulk of the tumor, a subset of cancer cells called cancer stem cells (or tumor-initiating cells) is characterized by self-renewal, unlimited proliferative potential, expression of multidrug-resistance ...
Modeling tumorspheres reveals cancer stem cell niche building and plasticity
(Elsevier Science, 2019-11)
Cancer stem cells have been shown to be critical to the development of a variety of solid cancers. The precise interplay mechanisms between cancer stem cells and the rest of a tissue are still not elucidated. To shed light ...