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Mostrando ítems 11-20 de 322
Structure of excitatory synapses and GABA
(American Society for Biochemistry and Molecular Biology Inc., 2014)
Formation, maintenance, and activity of excitatory and inhibitory synapses are essential for neuronal network function. Cell adhesion molecules (CAMs) are crucially involved in these processes. The CAM neuroplastin-65 ...
Neddylation inhibition impairs spine development, destabilizes synapses and deteriorates cognition
(Nature Publishing Group, 2015-02)
Neddylation is a ubiquitylation-like pathway that controls cell cycle and proliferation by covalently conjugating Nedd8 to specific targets. However, its role in neurons, nonreplicating postmitotic cells, remains unexplored. ...
Synaptic Activity Regulated mRNA-Silencing Foci for the Fine Tuning of Local Protein Synthesis at the Synapse
(Landes Bioscience, 2012)
The regulated synthesis of specific proteins at the synapse is important for neuron plasticity, and several localized mRNAs are translated upon specific stimulus. Repression of mRNA translation is linked to the formation ...
From synapses to behavior: development of a sensory-motor circuit in the leech
(John Wiley & Sons Inc, 2008-05)
The development of neuronal circuits has been advanced greatly by the use of imaging techniques that reveal the activity of neurons during the period when they are constructing synapses and forming circuits. This review ...
DLGS97/SAP97 is developmentally upregulated and is required for complex adult behaviors and synapse morphology and function
(2008)
The synaptic membrane-associated guanylate kinase (MAGUK) scaffolding protein family is thought to play key roles in synapse assembly and synaptic plasticity. Evidence supporting these roles in vivo is scarce, as a consequence ...
Comparative structural analysis of neuromuscular junctions in mice at different ages
(1998-04-01)
The authors studied the histochemical and ultrastructural modifications that occur in the neuromuscular junctions (NMJ) of fibularis longus muscles of mice with an age range of 3 to 21 months. Twenty-four male and female ...
Novel mRNA-silencing bodies at the synapse: A never-ending story
(Taylor & Francis, 2016-02)
Several cellular responses depend on translational regulation and in most cases, this involves the formation of cytoplasmic granules that contain repressed mRNAs. In neurons, numerous mRNAs travel along dendrites to be ...
Astrocytes and human cognition: Modeling information integration and modulation of neuronal activity
(Pergamon-Elsevier B.V. Ltd, 2010-11-01)
Recent research focusing on the participation of astrocytes in glutamatergic tripartite synapses has revealed mechanisms that support cognitive functions common to human and other mammalian species, such as learning, ...
Distinct localization of T cell Agrin during antigen presentation - evidence for the expression of Agrin receptor(s) in antigen-presenting cells
(Wiley-Blackwell, 2012-07-01)
Agrin is over-expressed by activated and autoimmune T cells, and synergizes with the T cell receptor (TCR) to augment cell activation. In the present study, we show that Agrin accumulates to distinct areas of the plasma ...