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Kinetic characterization of a novel cysteine peptidase from the protozoan Babesia bovis, a potential target for drug design
(Elsevier, 2020-12)
C1A cysteine peptidases have been shown to play an important role during apicomplexan invasion and egress of host red blood cells (RBCs) and therefore have been exploited as targets for drug development, in which peptidase ...
Molecular detection and differentiation of arthropod, fungal, protozoan, bacterial and viral pathogens of honeybees
(MDPI, 2022-05)
The honeybee Apis mellifera is highly appreciated worldwide because of its products, but also as it is a pollinator of crops and wild plants. The beehive is vulnerable to infections due to arthropods, fungi, protozoa, ...
Chronic infection with the protozoan Toxoplasma gondii prevents the development of experimental atopic dermatitis in mice
(Elsevier Ireland, 2019-11-02)
Background: Supporting the hypothesis thatT. gondii infection protects against allergy in humans we previously demonstrated that this infection can modulate not only the susceptibility to develop respiratory allergies in ...
Giardia spp., the most ubiquitous protozoan parasite in Argentina: Human, animal and environmental surveys reported in the last 40 years
(Springer, 2020-10)
Giardia is a parasite distributed worldwide and one of the most prevalent intestinal protozoa in Argentina. We analysed all the national information regarding the prevalence of Giardia infections in humans, animals and ...
Efficient oral vaccination by bioengineering virus-like particles with protozoan surface proteins
(Nature, 2019-12)
Intestinal and free-living protozoa, such as Giardia lamblia, express a dense coat of variant-specific surface proteins (VSPs) on trophozoites that protects the parasite inside the host’s intestine. Here we show that VSPs ...
Plataforma basada en proteínas de superficie de protozoarios para la generación de vacunas oralesPlatform for the generation of oral vaccines based on protozoan surface proteins
(Medicina (Buenos Aires), 2019-12)
La propagación internacional de enfermedades infecciosas constituye un problema global de seguridad sanitaria. La vacunación es una de las intervenciones en salud más exitosas y efectivas. La administración por vía oral ...
Characterization of proteolytic activities of Giardia lamblia with the ability to cleave His-tagged N-terminal sequences
(Elsevier Science, 2019-01)
Giardia lamblia is one of the most common protozoan infectious agents in the world and is responsible for diarrheal disease and chronic postinfectious illness. During the host-parasite interaction, proteases are important ...
Fatal Sarcocystis cruzi–induced eosinophilic myocarditis in a heifer in Uruguay
(American Association of Veterinary Laboratory Diagnosticians, 2019-07)
Sarcocystis spp. are causative agents of bovine eosinophilic myositis and/or myocarditis, which are chronic subclinical myopathies that are occasionally responsible for condemnation at slaughterhouses. Sarcocystis cruzi ...
A homolog of cyclophilin D is expressed in Trypanosoma cruzi and is involved in the oxidative stress–damage response
(Springer Nature, 2017-02)
Mitochondria have an important role in energy production, homeostasis and cell death. The opening of the mitochondrial permeability transition pore (mPTP) is considered one of the key events in apoptosis and necrosis, ...
Poly(ADP-ribose) metabolism in human parasitic protozoa
(Elsevier Science, 2020-08-22)
Poly(ADP-ribosyl)ation reactions constitute a post-translational protein modification synthesized in higher eukaryotes by a family of poly(ADP-ribose)polymerases (PARP) and catabolized mainly by poly(ADP-ribose) glycohydrolase ...