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CTCF: from insulators to alternative splicing regulation
(Nature Publishing Group, 2012-02)
The zinc-finger DNA-binding protein CTCF has been known for being a constituent of insulators. A recent paper in Nature reports an unforeseen intragenic role for CTCF that links DNA methylation with alternative splicing. ...
Cyclin T1 overexpression induces malignant transformation and tumor growth
(Landes Bioscience, 2010)
Human PTEFb is a protein kinase composed by CDK9 and Cyclin T that controls the elongation phase of RNA Pol II. This complex also affects the activation and differentiation program of lymphoid cells. In this study we found ...