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Core 1 O-N-acetylgalactosamine (O-GalNAc) glycosylation in the human cell nucleus
(De Gruyter, 2020-08)
Glycosylation is a very frequent post-translational modification in proteins, and the initiation of O-N-acetylgalactosamine (O-GalNAc) glycosylation has been recently described on relevant nuclear proteins. Here we evaluated ...
Highly glycosylated human alpha interferon: An insight into a new therapeutic candidate
(Elsevier Science, 2010-03)
The type I human interferon alpha (hIFN-α) family consists of small proteins that exert a multiplicity of biological actions including antiviral, antiproliferative and immunomodulatory effects. However, though administration ...
Photocatalyzed reductive fluoroalkylation of 2-acetoxyglycals towards the stereoselective synthesis of α-1-fluoroalkyl-: C -glycosyl derivatives
(Royal Society of Chemistry, 2020-11)
A benign, efficient, regio- and stereoselective protocol for the syntheses of α-1-fluoroalkyl-C-glycosyl compounds bearing CF3, C4F9, and C6F13 substituents on the anomeric carbon has been developed by a new methodology ...
Altered Glycosylation Contributes to Placental Dysfunction Upon Early Disruption of the NK Cell-DC Dynamics
(Frontiers Media, 2020-07)
Immune cells [e. g., dendritic cells (DC) and natural killer (NK) cells] are critical players during the pre-placentation stage for successful mammalian pregnancy. Proper placental and fetal development relies on balanced ...
N-glycosylation of trpm8 ion channels modulatestemperature sensitivity of cold thermoreceptor neuronsJOURNAL OF BIOLOGICAL CHEMISTRY (PRINT)J BIOL CHEM (PRINT)
(AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2012)
N-glycosylation of trpm8 ion channels modulates temperature sensitivity of cold thermoreceptor neuronsJOURNAL OF BIOLOGICAL CHEMISTRY (PRINT)J BIOL CHEM (PRINT)
(AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2012)
Synthetic lactulose amines: novel class of anticancer agents that induce tumor-cell apoptosis and inhibit galectin-mediated homotypic cell aggregation and endothelial cell morphogenesis
(Oxford Univ Press Inc, 2006-03)
Galectins, a family of structurally related carbohydrate-binding proteins, contribute to different events associated with cancer biology, including apoptosis, homotypic cell aggregation, angiogenesis and tumor-immune escape. ...
Bifunctional GM-CSF-derived peptides as tools for O-glycoengineering and protein tagging
(Elsevier Science, 2021-02)
Rapid development of effective biotherapeutics has been a concern during the last couple decades. In our work we designed two novel peptide tags, GMOP and mGMOP, derived from the N-terminal region of human granulocyte and ...
A comparative study of the O-3 reactivity of isomeric N-dimethylmaleoyl- protected d-glucosamine and d-allosamine acceptors
(Elsevier, 2011-04)
Four isomeric N-dimethylmaleoyl 4,6-O-benzylidene-protected d-hexosamine acceptors (2, 3, 4, and 5) with all possible configurations at C-1 and C-3 (e.g., derived from d-glucosamine and d-allosamine) were prepared, and the ...