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Mitochondrial dynamics, mitophagy and cardiovascular disease
(WILEY-BLACKWELL, 2016)
Cardiac hypertrophy is often initiated as an adaptive response to haemodynamic stress or myocardial injury, and allows the heart to meet an increased demand for oxygen. Although initially beneficial, hypertrophy can ...
Dysfunction of mitochondrial Lon protease and identification of oxidized protein in mouse brain following exposure to MPTP: Implications for Parkinson disease
(Elsevier, 2017)
Compelling evidence suggests that mitochondrial dysfunction leading to reactive oxygen species (ROS) production and protein oxidation could represent a critical event in the pathogenesis of Parkinson's disease (PD). ...
DT-diaphorase protects against autophagy induced by aminochrome dependent alpha synuclein oligomers
(Springer, 2017)
Alpha-synuclein (SNCA) oligomers have been reported to inhibit autophagy. Aminochrome-induced SNCA oligomers are neurotoxic, but the flavoenzyme DT-diaphorase prevents both their formation and their neurotoxicity. However, ...
Endoplasmic reticulum: ER stress regulates mitochondrial bioenergetics
(Elsevier, 2012)
Endoplasmic reticulum (ER) stress activates an adaptive unfolded protein response (UPR) that facilitates
cellular repair, however, under prolonged ER stress, the UPR can ultimately trigger apoptosis thereby terminating
damaged ...
Are Dopamine Oxidation Metabolites Involved in the Loss of Dopaminergic Neurons in the Nigrostriatal System in Parkinson's Disease?
(American Chemical Society, 2017)
© 2017 American Chemical Society. In 1967, L-dopa was introduced as part of the pharmacological therapy of Parkinson's disease (PD) and, in spite of extensive research, no additional effective drugs have been discovered ...
Noxious iron–calcium connections in neurodegeneration
(Frontiers Media, 2019)
Iron and calcium share the common feature of being essential for normal neuronal function. Iron is required for mitochondrial function, synaptic plasticity, and the development of cognitive functions whereas cellular calcium ...
Calcium signaling in insulin action on striated muscle
(Churchill Livingstone, 2014)
© 2014 Elsevier Ltd. Striated muscles (skeletal and cardiac) are major physiological targets of insulin and this hormone triggers complex signaling pathways regulating cell growth and energy metabolism. Insulin increases ...
Mifepristone for treatment of metabolic syndrome: beyond cushing’s syndrome
(Frontiers Media, 2020)
A growing body of research indicates that cortisol, the glucocorticoid product of the activation of the hypothalamic-pituitary-adrenal axis, plays a role in the pathophysiology of metabolic syndrome. In this regard, chronic ...
The antioxidant N-acetylcysteine prevents the mitochondrial fragmentation induced by soluble amyloid-β peptide oligomers
(2012)
Background: Soluble amyloid-β peptide oligomers (AβOs), which are centrally involved in the pathogenesis of Alzheimer's disease, trigger Ca 2+ influx through N-methyl-D-aspartate receptors and stimulate reactive oxygen ...
Alterations in Cytosolic and Mitochondrial [U-C-13] Glucose Metabolism in a Chronic Epilepsy Mouse Model
(Soc Neuroscience, 2017)
Temporal lobe epilepsy is a common form of adult epilepsy and shows high resistance to treatment. Increasing evidence has suggested that metabolic dysfunction contributes to the development of seizures, with previous studies ...