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Adipose-derived mesenchymal stem/stromal cells: from the lab bench to the basic concepts for clinical translation
(Instituto de Histología y Embriología "Dr. Mario Burgos", 2018-12)
In the last years, much work has shown that the most effective repair system of the body is represented by stem cells, which are defined as undifferentiated precursors that own unlimited or prolonged self-renewal ability, ...
Systemically administered allogeneic mesenchymal stem cells do not aggravate the progression of precancerous lesions: A new biosafety insight
(BioMed Central, 2018-05)
Background: Mesenchymal stem cells (MSCs) are a heterogeneous subset of stromal cells currently tested for multiple therapeutic purposes. Their potential to home into tumors, to secrete trophic/vasculogenic factors, and ...
Brief report: The potential role of epigenetics on multipotent cell differentiation capacity of mesenchymal stromal cells
(Alphamed Press, 2013-01)
Human umbilical cord perivascular cells (HUCPVCs) are a readily available source of mesenchymal stromal cells (MSCs) for cell therapy. We were interested in understanding how differences from human bone marrow (BM)-derived ...
Mesenchymal stromal cells overexpressing vascular endothelial growth factor in ovine myocardial infarction
(Nature Publishing Group, 2015-06)
Mesenchymal stromal cells (MSCs) are cardioprotective in acute myocardial infarction (AMI). Besides, we have shown that intramyocardial injection of plasmid-VEGF165 (pVEGF) in ovine AMI reduces infarct size and improves ...
Retina stem cells, hopes and obstacles
(Baishideng Publishing, 2021-10-26)
Retinal degeneration is a major contributor to visual dysfunction worldwide. Although it comprises several eye diseases, loss of retinal pigment epithelial (RPE) and photoreceptor cells are the major contributors to their ...
Androgens modify Wnt agonists/antagonists expression balance in dermal papilla cells preventing hair follicle stem cell differentiation in androgenetic alopecia
(Elsevier Ireland, 2017-01)
In androgenetic alopecia, androgens impair dermal papilla-induced hair follicle stem cell (HFSC) differentiation inhibiting Wnt signaling. Wnt agonists/antagonists balance was analyzed after dihydrotestosterone (DHT) ...
Mesenchymal stem cell therapy facilitates donor lung preservation by reducing oxidative damage during ischemia
(Hindawi Publishing Corporation, 2019-08)
Lung transplantation is a lifesaving therapy for people living with severe, life-threatening lung disease. The high mortality rate among patients awaiting transplantation is mainly due to the low percentage of lungs that ...
The inflammatory cytokine TNF contributes with RAC3-induced malignant transformation
(Univ Mainz-med Dept, 2018-11)
RAC3 is a coactivator of steroid receptors and NF-kB. It is usually overexpressed in several tumors, contributes to maintain cancer stem cells and also to induce them when is overexpressed in non-tumoral cells. In this ...
Mesenchymal stem cell therapy improves spatial memory and hippocampal structure in aging rats
(Elsevier Science, 2019-11-18)
There is a growing interest in the potential of mesenchymal stem cells (MSCs) for implementing regenerative medicine in the brain as they have shown neurogenic and immunomodulatory activities. We assessed the effect of ...
Human adipose-derived mesenchymal stem cell-conditioned medium ameliorates polyneuropathy and foot ulceration in diabetic BKS db/db mice
(BioMed Central, 2020-05)
Background: Diabetic polyneuropathy (DPN) is the most common and early developing complication of diabetes mellitus, and the key contributor for foot ulcers development, with no specific therapies available. Different ...