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The discovery BPD (D-BPD) program: Study protocol of a prospective translational multicenter collaborative study to investigate determinants of chronic lung disease in very low birth weight infants
(BioMed Central, 2019-07-06)
Background: Premature birth is a growing and serious public health problem affecting more than one of every ten infants worldwide. Bronchopulmonary dysplasia (BPD) is the most common neonatal morbidity associated with ...
Controlled Drug Delivery via the Lung
(John Wiley & Sons Inc, 2021)
The lungs fulfill the vital function of transporting and exchanging breathing air. The respiratory tract is considered an excellent delivery route for local and noninvasive administration of active ingredients, even when ...
Mesenchymal stem cell therapy facilitates donor lung preservation by reducing oxidative damage during ischemia
(Hindawi Publishing Corporation, 2019-08)
Lung transplantation is a lifesaving therapy for people living with severe, life-threatening lung disease. The high mortality rate among patients awaiting transplantation is mainly due to the low percentage of lungs that ...
Study of Helicobacter pylori infection on lung using an animal model
(Elsevier, 2018-10)
Helicobacter pylori infection has been reported to be associated with extra-digestive disorders such as respiratory diseases; however, the impact of H. pylori on lung is incompletely understood. Inflammatory response is ...
Mitochondrial Alterations and Oxidative Stress in Cystic Fibrosis
(Springer, 2019)
Cystic fibrosis (CF) is the most frequent autosomal recessive disease and is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Since the discovery of the deletion in the phenylalanine ...
Lipopolymers and lipids from lung surfactants in association with N-acetyl-l-cysteine: Characterization and cytotoxicity
(Elsevier Ireland, 2020-09)
In the present work, we obtained polymeric diacetylene liposomes that can associate N-Acetyl-L-Cysteine (NAC),a broad spectrum mucolytic. The reason for studying these formulations is that they could be applied in thefuture ...
Inflammatory response induced by Helicobacter pylori infection in lung
(Academic Press Ltd - Elsevier Science Ltd, 2020-05)
Helicobacter pylori is a microorganism that in the last years has been associated with extragastric disorders such as respiratory diseases, however, its impact on lung is partially understood. The aim of this work was to ...
Air particulate matter exacerbates lung response on Sjögren's Syndrome animals
(Elsevier Gmbh, 2014-11)
Epidemiological studies have associated air particulate matter (PM) inhalation with a decline in lung function and increased morbo-mortality due to cardiorespiratory diseases, particularly in susceptible populations. ...
Cytotoxic effects of copper overload on human-derived lung and liver cells in culture
(Elsevier Science, 2012-07)
Background: Copper (Cu) is an essential trace metal used as a catalytic cofactor for many enzymes. However, it can have nocive effects when it participates in the Fenton reaction, producing reactive oxygen species (ROS). ...