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Chitosan-triclosan particles modulate inflammatory signaling in gingival fibroblasts
(Wiley, 2018-04)
Background and Objectives: An important goal of periodontal therapy is the modulation of the inflammatory response. To this end, several pharmacological agents have been evaluated. Triclosan corresponds to an antibacterial ...
Levels of interleukin-1 beta, -8, and -10 and RANTES in gingival crevicular fluid and cell populations in adult periodontitis patients and the effect of periodontal treatment.
(American Academy of Periodontology, 2000-10)
Background: Various cytokines have been identified at sites of chronic inflammation such as periodontitis. Cytokines are synthesized in response to bacteria and their products, inducing and maintaining an inflammatory ...
The increased expression of receptor activator of nuclear-κB ligand (RANKL) of multiple myeloma bone marrow stromal cells is inhibited by the bisphosphonate ibandronate
(2010)
The receptor activator of nuclear factor-kappaB ligand (RANKL) and interleukin-1beta are osteoclast activating factors which are abnormally expressed in bone marrow stromal cells and plasma cells of multiple myeloma patients. ...
IL-6 −572C>G and CARD8 304T>A genetic polymorphisms are associated with the absolute neutrophil count in patients with hematological malignancies under chemotherapy: An application of multilevel models to a preliminary pharmacogenetic study
(Dove Medical Press, 2020)
Purpose: Neutropenia is a common event in patients undergoing cytotoxic chemotherapy for the treatment of a hematological malignancy. Some polymorphisms, as IL-6 -572C>G (rs1800796), IL-beta -31 G>A (rs1143627), and CARD8 ...
The Increased Expression of Receptor Activator of Nuclear-kappa B Ligand (RANKL) of Multiple Myeloma Bone Marrow Stromal Cells Is Inhibited by the Bisphosphonate Ibandronate
(WILEY-LISS, DIV JOHN WILEY & SONS INC, 2010-09-01)
The receptor activator of nuclear factor-kappaB ligand (RANKL) and interleukin-1beta are osteoclast activating factors which are abnormally
expressed in bone marrow stromal cells and plasma cells of multiple myeloma ...
In vitro phenotype induction of circulating monocytes: CD16 and CD163 analysis
(Dove Medical Press, 2021)
Introduction: CD14 (monocyte differentiation antigen, LPS binding protein - endotoxin receptor) and CD16 (FcyRIII, Low-affinity receptor for IgG) define three subpopulations of circulating monocytes with different inflammatory ...
Purinergic Signaling as a Regulator of Th17 Cell Plasticity
(Public Library Science, 2016)
T helper type 17 (Th17) lymphocytes, characterized by the production of interleukin-17 and other pro-inflammatory cytokines, are present in intestinal lamina propria and have been described as important players driving ...
Antinociception induced by rosuvastatin in murine neuropathic pain
(Elsevier, 2018-06)
Background: Neuropathic pain, and subsequent hypernociception, can be induced in mice by paclitaxel (PTX) administration and partial sciatic nerve ligation (PSNL). Its pharmacotherapy has been a clinical challenge, due to ...
All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation
(2007)
We demonstrate that all-trans retinoic acid (RA) induces Ill adaptive T regulatory cells (A-Tregs) to acquire a gut-homing phenotype (alpha 4 beta 7(+) CC chemokine receptor 9(+)) and the capacity to home to the lamina ...
New knowledge of the pathogenesis of periodontal disease.
(Quintessence Publishing, 2004-10)
The aim of this study was to evaluate the relationship between the accumulation of interleukins IL-1beta, TNF-alpha, IL-8, and chemokine RANTES (Regulated upon Activation Normal T-cell Expressed and Secreted) in gingival ...