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Src-family kinase inhibitors block early steps of caveolin-1-enhanced lung metastasis by melanoma cells
(Elsevier, 2020)
In advanced stages of cancer disease, caveolin-1 (CAV1) expression increases and correlates with increased migratory and invasive capacity of the respective tumor cells. Previous findings from our laboratory revealed that ...
Binding of Competitive Inhibitors to S-Chymotrypsin in the Alkaline pH Region. Competitive Inhibition Kinetics and Proton-Uptake Measurements
(1970)
The binding of the three competitive inhibitors benzyl alcohol, tryptophol, and N-acetyl-D-tryptophanamide to α- and δ-chymotrypsins was studied over the pH range 7 to 11 by competitive inhibition kinetics using ...
HIV-1 resistance patterns to integrase inhibitors in Chilean patients with virological failure on raltegravir-containing regimens
(Mediscript, 2020)
In this viewpoint we would like to describe our results in terms of resistance pattern in Chilean patients with virological failure (VF) on raltegravir (RAL)-containing-regimens and highlight the need for the concomitant ...
Heterologous expression of an α‑amylase inhibitor from common bean (Phaseolus vulgaris) in Kluyveromyces lactis and Saccharomyces cerevisiae
(BioMed Central, 2017-06-15)
Background: Phaseolamin or alpha-amylase inhibitor 1 (alpha AI) is a glycoprotein from common beans (Phaseolus vulgaris L.) that inhibits some insect and mammalian alpha-amylases. Several clinical studies support the ...
Abscisic acid and jasmonic acid affect proteinase inhibitor activities in barley leaves
(URBAN & FISCHER VERLAG, 2004-04)
Proteinase inhibitor (PI) accumulation has been described as a plant defense response against insects and pathogens. The induction of Pis is known to be regulated by endogenous chemical factors including phytohormones. We ...
Vegetative and physiological responses of “Emerald” blueberry to ammoniacal sources with a nitrification inhibitor
(Springer, 2020)
The nitrogen nutrition in blueberry has been studied by some authors; however, the effect of N-nitrate or N-ammoniacal fertilizers with nitrification inhibitors on plant growth and physiology has not been known. The aim ...
Identification of novel 11β-HSD1 inhibitors by combined ligand- and structure-based virtual screening
(2014)
11 beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) converts cortisone to cortisol in a NADPH dependent manner. Overexpression of 11β-HSD1 in key metabolic tissues is related to the development of type 2 diabetes, ...
Nitric oxide synthase inhibitor improves de novo and long-term l-DOPA-induced dyskinesia in hemiparkinsonian rats
(2011-06)
Inhibitors of neuronal and endothelial nitric oxide synthase decrease l-3,4-dihidroxifenilalanine
(l-DOPA)-induced dyskinesias in rodents. The mechanism of nitric oxide inhibitor action is
unknown. The aims of the present ...
Durability of efavirenz compared with boosted protease inhibitor based regimens in antiretroviral naive patients in the Caribbean and Central and South America
(Oxford University Press, 2018)
Background. Efavirenz (EFV) and boosted protease inhibitors (bPIs) are still the preferred options for firstline antiretroviral regimens (firstline ART) in Latin America and have comparable short-term efficacy. We assessed ...
Easy and rapid preparation of benzoylhydrazides and their diazene derivatives as inhibitors of 15-lipoxygenase
(Elsevier Ltd, 2017)
© 2017 Elsevier Ltd Two series of diaza derivatives were prepared by solvent-free condensation of benzoic acid and 4-substituted phenylhydrazines in order to obtain phenylhydrazides (HYD series) and, by oxidation of these ...