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Inhibition of iron and copper uptake by iron, copper and zinc
(SOCIEDAD BIOLGIA CHILE, 2005-05-05)
Interactions of micronutrients can affect absorption and bioavailability of other nutrients by a number of
mechanisms. In aqueous solutions, and at higher uptake levels, competition between elements with similar
chemical ...
Uncoupling the MgATP-induced inhibition and aggregation of Escherichia coli phosphofructokinase-2 by C-terminal mutations
(ELSEVIER, 2008-06-11)
Binding of MgATP to an allosteric site of Escherichia coli phosphofructokinase-2 (Pfk-2) provoked inhibition and a dimer-tetramer (D-T) conversion of the enzyme. Successive deletions of up to 10 residues and point mutations ...
A Zindo/1 Study of the Cannabinoid-Mediated Inhibition of Adenylyl Cyclase
(University of Tehran, 2003-09-06)
We present here the results of a formal structure-property relationship study
carried out for 1 CB - and 2 CB -mediated inhibition of adenylyl cyclase
(ADC) by a group of classical cannabinoid derivatives. The wave ...
Gold Nanoparticles and Microwave Irradiation Inhibit Beta-Amyloid Amyloidogenesis
(SPRINGER, 2008-11)
Peptide-Gold nanoparticles selectively attached to beta-amyloid protein (A beta) amyloidogenic aggregates were irradiated with microwave. This treatment produces dramatic effects on the A beta aggregates, inhibiting both ...
Trypanosoma cruzi calreticulin inhibits the complement lectinpathway activation by direct interaction with L-Ficolin
(Elsevier, 2014)
Trypanosoma cruzi, the agent of Chagas’ disease, the sixth neglected tropical disease worldwide, infects10–12 million people in Latin America. Differently from T. cruzi epimastigotes, trypomastigotes arecomplement-resistant ...
Tissue-specific inhibition and recovery of esterase activities in Lumbricus terrestris experimentally exposed to chlorpyrifos
(ELSEVIER, 2010)
Exposure and effect assessment of organophosphate (OP) pesticides generally involves the use of
cholinesterase (ChE) inhibition. In earthworm, this enzyme activity is often measured in homogenates
from the whole organism. ...
Inhibition of HIV-2(ROD) replication in a lymphoblastoid cell line by the alpha 1-antitrypsin Portland variant (alpha 1-PDX) and the decRVKRcmk peptide: comparison with HIV-1(LAI)
(EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2001-11)
We investigated the effects of alpha1-antitrypsine Portland variant (alpha1-PDX) and decanoylRVKRchloromethylketone (decRVKRcmk) on HIV-2(ROD) replication in the Jurkat lymphoblastoid cell line. To this end, cells were ...
Effects of t-butyl-4-hydroxyanisole and other phenolic antioxidants on tumoral cells and Trypanosoma parasites
(1988)
The antioxidant food additives 2(3)-tert-butyl-4-hydroxyanisole (BHA), 2,6-di(tert-butyl)-p-cresol (BHT) and the methyl and propyl esters of gallic acid inhibited Trypanosoma cruzi culture growth and oxygen consumption. ...
Endofacial competitive inhibition of the glucose transporter 1 activity by gossypol
(2009)
Gossypol is a natural disesquiterpene that blocks the activity of the mammalian facilitative hexose transporter GLUT1. In human HL-60 cells, which express GLUT1, Chinese hamster ovary cells overexpressing GLUT1, and human ...
Telomerase inhibition by a new synthetic derivative of the aporphine alkaloid boldine
(MDPI, 2018-04)
Telomerase, the enzyme responsible for cell immortality, is an important target in anti-cancer drug discovery. Boldine, an abundant aporphine alkaloid of Peumus boldus, is known to inhibit telomerase at non-toxic concentrations. ...