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Endothelial nitric oxide synthase genotypes and haplotypes modify the responses to sildenafil in patients with erectile dysfunction
(Nature Publishing GroupLondonInglaterra, 2013)
Polymorphism analysis in genes associated with meat tenderness in Nelore cattle
(2018-12-01)
The aims of this study were to identify haplotyped loci associated with meat tenderness (WBSF) in candidate genes and to search for new polymorphisms in these regions that influence such trait in Nelore cattle. Fifty-two ...
Genetic and biochemical markers of hydroxyurea therapeutic response in sickle cell anemia
(Biomed Central Ltd., 2013-10-09)
Background: Sickle cell anemia (SCA) presents a complex pathophysiology which can be affected by a number of modifying factors, including genetic and biochemical ones. In Brazil, there have been no studies verifying ...
eNOS haplotype associated with hypertension in obese children and adolescents
(NATURE PUBLISHING GROUP, 2011)
Objective: The aim of our study is to investigate whether genetic polymorphisms in the endothelial nitric oxide synthase (eNOS) gene (in the promoter region T(-786)C, in exon 7 (Glu298Asp) and in intron 4 (4b/4a)) or eNOS ...
Common matrix metalloproteinase 2 gene haplotypes may modulate left ventricular remodelling in hypertensive patients
(NATURE PUBLISHING GROUPLONDON, 2012-03)
Matrix metalloproteinases (MMPs) are involved in cardiac remodelling. We examined whether MMP-2 genetic polymorphisms are associated with hypertension and left ventricular (LV) remodelling in hypertensive patients. We ...
Association of haplotypes in the IL8 gene with susceptibility to chronic periodontitis in a Brazilian population
(ELSEVIER SCIENCE BV, 2010)
Background: Interleukin 8 (IL-8) is a chemokine related to the initiation and amplification of acute and chronic inflammatory processes. Polymorphisms in the IL8 gene have been associated with inflammatory diseases. We ...
Endothelial nitric oxide synthase haplotypes are related to blood pressure elevation, but not to resistance to antihypertensive drug therapy
(Lippincott Williams & WilkinsPhiladelphiaEUA, 2006)
Haplotypes from the SLC45A2 gene are associated with the presence of freckles and eye, hair and skin pigmentation in Brazil
(2017-03-01)
The Solute Carrier Family 45, Member 2 (SLC45A2) gene encodes the Membrane-Associated Transporter Protein (MATP), which mediates melanin synthesis by tyrosinase trafficking and proton transportation to melanosomes. At least ...
Association of haplotypes in the IL8 gene with susceptibility to chronic periodontitis in a Brazilian population
(Elsevier B.V., 2010-09-06)
Background: Interleukin 8 (IL-8) is a chemokine related to the initiation and amplification of acute and chronic inflammatory processes. Polymorphisms in the IL8 gene have been associated with inflammatory diseases. We ...
Vascular endothelial growth factor genotypes and haplotypes are associated with pre-eclampsia but not with gestational hypertension
(OXFORD UNIV PRESS, 2009)
Vascular endothelial growth factor (VEGF) is relevant for normal pregnancy, and abnormalities in VEGF functions are associated with hypertensive disorders of pregnancy. Because there are few studies on how VEGF genetic ...