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Network approach identifies Pacer as an autophagy protein involved in ALS pathogenesis
(BMC, 2019)
BackgroundAmyotrophic lateral sclerosis (ALS) is a multifactorial fatal motoneuron disease without a cure. Ten percent of ALS cases can be pointed to a clear genetic cause, while the remaining 90% is classified as sporadic. ...
Mitochondrial genome instability in colorectal adenoma and adenocarcinoma
(2015-11-01)
Mitochondrial dysfunction is regarded as a hallmark of cancer progression. In the current study, we evaluated mitochondrial genome instability and copy number in colorectal cancer using Next Generation Sequencing approach ...
The buffalo genome and the application of genomics in animal management and improvement
(2013-11-28)
The publication of the human genome sequence in 2001 was a major step forward in knowledge necessary to understand the variations between individuals. For farmed species, genomic sequence information will facilitate the ...
Transposable elements as a potential source for understanding the fish genome
(2011)
Transposable elements are repetitive sequences with the capacity to move inside of the genome. They constitute the majority of the eukaryotic genomes, and are extensively present in the human genome, representing more than ...
Species relationships among the wild B genome of Arachis species (section Arachis) based on FISH mapping of rDNA loci and heterochromatin detection: a new proposal for genome arrangement
(Springer, 2010-05)
Arachis hypogaea is an allotetraploid species with low genetic variability. Its closest relatives, all of the genus Arachis, are important sources of alleles for peanut breeding. However, a better understanding of the ...
Transcriptionally active LTR retrotransposons in Eucalyptus genus are differentially expressed and insertionally polymorphic
(BioMed Central, 2015-08-14)
In Eucalyptus genus, studies on genome composition and transposable elements (TEs) are particularly scarce. Nearly half of the recently released Eucalyptus grandis genome is composed by retrotransposons and this data ...
Integrating cytogenetics and genomics in comparative evolutionary studies of cichlid fish
(Biomed Central Ltd., 2012-09-09)
Background: The availability of a large number of recently sequenced vertebrate genomes opens new avenues to integrate cytogenetics and genomics in comparative and evolutionary studies. Cytogenetic mapping can offer ...
The genome sequence of Dyella jiangningensis FCAV SCS01 from a lignocellulose-decomposing microbial consortium metagenome reveals potential for biotechnological applications
(2018-04-01)
Cellulose and its associated polymers are structural components of the plant cell wall, constituting one of the major sources of carbon and energy in nature. The carbon cycle is dependent on cellulose-and lignin-decomposing ...
Functional Annotation of All Salmonid Genomes (FAASG): an international initiative supporting future salmonid research, conservation and aquaculture
(BIOMED Central Ltd., 2017)
We describe an emerging initiative - the 'Functional Annotation of All Salmonid Genomes' (FAASG), which will leverage the extensive trait diversity that has evolved since a whole genome duplication event in the salmonid ...