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Insulin-degrading enzyme: Structure-function relationship and its possible roles in health and disease
(Bentham Science Publishers, 2009-11)
Insulin-degrading enzyme (IDE) or insulysin is a highly conserved Zn 2+-dependent endopeptidase with an "inverted" HxxEH motif. In vivo, IDE contributes to regulate the steady state levels of peripheral insulin and cerebral ...
Molecular adaptations of NADP-malic enzyme for its function in C4 photosynthesis in grasses
(Palgrave Macmillan, 2019-07)
In C4 grasses of agronomical interest, malate shuttled into the bundle sheath cells is decarboxylated mainly by nicotinamide adenine dinucleotide phosphate (NADP)-malic enzyme (C4-NADP-ME). The activity of C4-NADP-ME was ...
Overcoming differences: The catalytic mechanism of metallo-β-lactamases
(Elsevier Science, 2015-07)
Metallo-β-lactamases are the latest resistance mechanism of pathogenic and opportunistic bacteria against carbapenems, considered as last resort drugs. The worldwide spread of genes coding for these enzymes, together with ...
Human α-galactosidase a mutants: Priceless tools to develop novel therapies for fabry disease
(MDPI AG, 2021-06)
Fabry disease (FD) is a lysosomal storage disease caused by mutations in the gene for the α-galactosidase A (GLA) enzyme. The absence of the enzyme or its activity results in the accumulation of glycosphingolipids, mainly ...
Functionalized hierarchical wrinkled-silica spheres for laccases immobilization
(Springer, 2021-02)
Functionalized mesoporous SiO2 are common supports for some enzymes of industrial interest, such as laccases. However, the incorporation of specific functionalities and the loading of enzymes with dimensions close to the ...
Changes in quality and composition of sunflower oil during enzymatic degumming process
(Elsevier Science, 2014-02-14)
The objective of this study was to examine the effect of the enzymatic degumming process on composition of crude sunflower oil. To analyze the crude and degummed oils, different parameters were determined. Phosphorous ...
Antarctic bioprospecting: in pursuit of microorganisms producing new antimicrobials and enzymes
(Springer, 2018-07)
Intensive efforts are being made to find new compounds with antimicrobial activity. The search for these novel bio-products in sparsely explored environments may be the key to providing solutions for many emerging problems. ...
Waterborne carbon nanotube ink for the preparation of electrodes with applications in electrocatalysis and enzymatic biosensing
(Pergamon-Elsevier Science Ltd, 2018-10)
Conductive inks with optimal properties for amperometric sensor fabrication are key materials for low cost and high performance electrodes printed on flexible substrates. In this work, electrodes made with a carbon nanotube ...
Partial purification of proteolytic enzymes and characterization of trypsin from merluccius hubbsi by-products
(Wolters Kluwer, 2015-12)
Proteolytic enzymes have been detected and partially purified from Merluccius hubbsiviscera. Crude proteinase extract exhibited its maximal activity at pH 7.94, 59.52ºC and33.93 minutes using azocaseín as a substrate. The ...
Amylase-Functionalized mesoporous silica thin films as robust biocatalyst platforms
(American Chemical Society, 2010-02)
A robust biocatalyst was produced by immobilization of R-amylase into mesoporous silica thin films with local order pore structure and 11 nm pore diameter, supported on glass stripes. The activity of this novel catalyst ...