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Generation of a Chinese Hamster Ovary Cell Line Producing Recombinant Human Glucocerebrosidase
(HINDAWI PUBLISHING CORPORATIONNEW YORK, 2012)
Impaired activity of the lysosomal enzyme glucocerebrosidase (GCR) results in the inherited metabolic disorder known as Gaucher disease. Current treatment consists of enzyme replacement therapy by administration of exogenous ...
In search of mechanisms associated with mesenchymal stem cell-based therapies for acute kidney injury
(AACB by Associated BusinessChippendale, 2013-11)
Acute kidney injury (AKI) is classically described as a rapid loss of kidney function. AKI affects more than 15% of all hospital admissions and is associated with elevated mortality rates. Although many advances have ...
Fabry disease: clinical and genotypic aspects of three cases in first degree relatives
(Sociedade Brasileira de Dermatologia, 2014-01-01)
Fabry disease is an X-linked, lysosomal storage disease caused by the inherited deficiency of the enzyme α-galactosidase A. The diagnosis is usually late, with renal, cardiovascular and/or cerebral complications that reduce ...
Guidelines for diagnosis and treatment of Hunter Syndrome for clinicians in Latin America
(Sociedade Brasileira de Genética, 2014)
This review aims to provide clinicians in Latin America with the most current information on the clinical aspects, diagnosis,
and management of Hunter syndrome, a serious and progressive disease for which specific treatment ...
Influence of Titanium Alloy Scaffolds on Enzymatic Defense against Oxidative Stress and Bone Marrow Cell Differentiation
(2020-01-01)
Studies have been directed towards the production of new titanium alloys, aiming for the replacement of Ti-6 Aluminium-4 Vanadium (TiAlV) alloy in the future. Many mechanisms related to biocompatibility and chemical ...
In vitro transdentinal effect of low-level laser therapy
(2013-05-01)
Low-level laser therapy (LLLT) has been used for the treatment of dentinal hypersensitivity. However, the specific LLL dose and the response mechanisms of these cells to transdentinal irradiation have not yet been demonstrated. ...
In vitro transdentinal effect of low-level laser therapy
(Institute of Physics - IOPBristol, 2013-05)
Low-level laser therapy (LLLT) has been used for the treatment of dentinal hypersensitivity. However, the specific LLL dose and the response mechanisms of these cells to transdentinal irradiation have not yet been demonstrated. ...
Crystallization and preliminary X-ray crystallographic analysis of chorismate synthase from Mycobacterium tuberculosis
(Blackwell Munksgaard, 2004-11-01)
The enzymes of the shikimate pathway are potential targets for the development of new therapies because they are essential for bacteria but absent from mammals. The last step in this pathway is performed by chorismate ...
Generation of Polyclonal Antibodies Against Recombinant Human Glucocerebrosidase Produced in Escherichia coli
(HUMANA PRESS INC, 2010)
Deficiency of the lysosomal glucocerebrosidase (GCR) enzyme results in Gaucher`s disease, the most common inherited storage disorder. Treatment consists of enzyme replacement therapy by the administration of recombinant ...