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Computational and synthetic target-based approaches to the discovery of novel anticonvulsant compounds
(Bentham Science Publishers, 2021-05)
Background: During the past decades, an important number of anticonvulsant drugs have been incorporated into the collection of drugs to treat epilepsy. However, two main difficulties remain unsolved in therapy: the development ...
Amphiphilic electrospun scaffolds of PLLA-PEO-PPO block copolymers: preparation, characterization and drug-release behaviour
(Royal Society of Chemistry, 2017-01)
Biocompatible amphiphilic copolymers are attractive candidates for the fabrication of electrospun scaffolds to be used for tissue engineering and the delivery of biologically active compounds. The amphiphilic block copolymers ...
A quality by design approach for optimization of Lecithin/Span® 80 based nanoemulsions loaded with hydrophobic drugs
(Elsevier Science, 2021-01)
Lately, nanoemulsions loaded with hydrophobic drugs have been successfully developed to improve the treatment of several global diseases. On this subject, a detailed study of the crucial role of the excipients and the ...
Magnetic nanoparticles for drug targeting: From design to insights into systemic toxicity. Preclinical evaluation of hematological, vascular and neurobehavioral toxicology
(Royal Society of Chemistry, 2017-04)
A simple two-step drug encapsulation method was developed to obtain biocompatible magnetic nanocarriers for the potential targeted treatment of diverse diseases. The nanodevice consists of a magnetite core coated with ...
Identification of Trypanosoma cruzi Polyamine Transport Inhibitors by Computational Drug Repurposing
(Frontiers Research Foundation, 2019-10)
Trypanosoma cruzi is the causative agent of Chagas disease, a parasitic infection endemic in Latin America. In T. cruzi the transport of polyamines is essential because this organism is unable to synthesize these compounds ...
Drug abuse prevention model using ADDIE and CBT for primary school students
(Universidad del Zulia, 2019)
Progresses in the field of drug design to combat tropical protozoan parasitic diseases
(Bentham Science Publishers, 2006-02)
The progresses made in the field of drug design to combat tropical protozoan parasitic diseases, such as Chagas' disease, leishmaniasis, and sleeping sickness are discussed. This article is focused on different approaches ...
Evaluation of the Drug Release Kinetics in Assembled Modular Systems Based on the Dome Matrix Technology
(John Wiley & Sons Inc, 2020-06-10)
Mathematical models are an important tool in pharmaceutical formulationsdevelopment, to evaluate in vitro and in vivo drug release processes and to optimize the design of new systems. Dome Matrix technology allows the ...