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Hyperglycemia differentially affects maternal and fetal DNA integrity and DNA damage response
(2016-02-12)
Objective: Investigate the DNA damage and its cellular response in blood samples from both mother and the umbilical cord of pregnancies complicated by hyperglycemia. Methods: A total of 144 subjects were divided into 4 ...
Response of the G2-prophase checkpoint to genotoxic drugs in lymphocytes from healthy individuals
(Society of Biology of Chile, 2012)
We analyzed the in vitro effects of the anti-tumoral drugs doxorubicin, cytosine arabinoside and hydroxyurea on the G2-prophase checkpoint in lymphocytes from healthy individuals. At biologically equivalent concentrations, ...
p8/nupr1 regulates DNA-repair activity after double-strand gamma irradiation-induced DNA damage
(Wiley, 2009-12)
The stress protein p8 is a small, highly basic, unfolded, and multifunctional protein. We have previously shown that most of its functions are exerted through interactions with other proteins, whose activities are thereby ...
Screening methylation of DNA repair genes in the oral mucosa of chronic smokers
(2018-08-01)
Objective: The aim of this study was to evaluate the epigenetic changes in the process of oral carcinogenesis by screening the methylation of repair genes in chronic smokers. Design: Two groups were formed: Group 1: 16 ...
Hydrogen peroxide and Helicobacter pylori extract treatment combined with APE1 knockdown induce DNA damage, G2/M arrest and cell death in gastric cancer cell line
(2020-12-01)
Chronic inflammation resulting from Helicobacter pylori (H. pylori) infection, the major risk factor for gastric cancer, results in increased release of reactive oxygen species (ROS), promoting oxidative stress and DNA ...
CPDs and 6-4PPs play different roles in UV-induced cell death in normal and NER-deficient human cells
(ELSEVIER SCIENCE BV, 2008)
Ultraviolet (UV) light generates two major DNA lesions: cyclobutane pyrimidine dimers (CPDs) and pyrimidine-(6-4)-pyrimidone photoproducts (6-4PPs), but the specific participation of these two lesions in the deleterious ...
Progression of chromosomal damage induced by etoposide in G2 phase in a DNA-PKcs deficient context
(Springer, 2015-12)
Etoposide (ETO), a drug used for the treatment of human tumors, is associated with the development of secondary malignancies. Recently, therapeutic strategies have incorporated chemosensitizing agents to improve the tumoral ...
How Trypanosoma Cruzi Deals With Oxidative Stress: Antioxidant Defence And Dna Repair Pathways
(Elsevier Science BVAmsterdam, 2016)
Helicobacter Pylori Infection Modulates The Expression Of Mirnas Associated With Dna Mismatch Repair Pathway
(Wiley-BlackwellHoboken, 2017)
Resistance to ultraviolet-induced apoptosis in DNA repair deficient growth arrested human fibroblasts is not related to recovery from RNA transcription blockage
(ELSEVIER SCIENCE BV, 2008)
The impact of ultraviolet (UV-C) photoproducts on apoptosis induction was investigated in growth arrested (confluent) and proliferating human primary fibroblasts. Confluent fibroblasts were more resistant to UV-C-induced ...