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Peripheral neuroimmunoendocrine interactions: contribution of TNFRp55 to the circadian synchronization of progesterone and cytokine production in joints of mice in late pregnancy
(Karger, 2018-12)
Circadian rhythms are generated by the suprachiasmatic nucleus of the hypothalamus and involve rhythmic expression of clock genes and proteins. This rhythmicity is transferred to peripheral tissues by neural and hormonal ...
Increased splenocyte proliferative response and cytokine production in β-endorphin-deficient mice
(Elsevier Science, 2002-10)
We used β-endorphin-deficient mice as a novel approach to confirm the physiological role that opioid peptides play in the development or regulation of the immune system. We found that mice lacking β-endorphin possessed an ...
Cytokine-Enhanced Vaccine and Suicide Non-Viral Gene Therapy in Advanced Metastatic Melanoma Patients: Two Case Reports
(Science Repository, 2020-05)
The prognostic for metastatic melanoma is very poor when treated with standard cytotoxic chemotherapies and it is often refractory to check point inhibitors and/or molecular targets. In this context the development of new ...
Heregulin drives endocrine resistance by altering il-8 expression in er-positive breast cancer
(MDPI AG, 2020-10)
Sustained HER2/HER3 signaling due to the overproduction of the HER3 ligand heregulin (HRG) is proposed as a key contributor to endocrine resistance in estrogen receptor-positive (ER+) breast cancer. The molecular mechanisms ...
Cytokines and chemokines in testicular inflammation: A brief review
(Wiley-liss, Div John Wiley & Sons Inc, 2009-08)
A wide spectrum of data in the literature shows the relevance of cytokines as paracrine regulators of spermatogenesis and steroidogenesis in the normal testis. In this brief review, we highlight the relevance of cytokines ...
Effect of TGF-b1 stimulation on the secretome of human adipose-derived mesenchymal stromal cells
(Wiley, 2015-08)
Adipose tissue is an attractive source of mesenchymal stromal cells (MSCs) owing to the relative ease of obtaining large volumes with more MSC abundance compared with other sources. Increasing evidence supports the fact ...
Pro-inflammatory cytokines enhance dilatation of bile canaliculi caused by cholestatic antibiotics
(Pergamon-Elsevier Science Ltd, 2019-08)
Many drugs can induce liver injury, characterized by hepatocellular, cholestatic or mixed hepatocellular-cholestatic lesions. While an inflammatory stress is known to aggravate hepatocellular injury caused by some drugs ...
Lack of TNFR p55 results in heightened expression of ifn-γ and IL-17 during the development of reactive arthritis
(American Association of Immunologists, 2010-10)
Reactive arthritis (ReA) is a type of arthritis originating from certain gastrointestinal or genitourinary infections. In previous studies, we reported the development of progressive Yersinia enterocolitica-induced ReA in ...
Cytokine Production but Lack of Proliferation in Peripheral Blood Mononuclear Cells from Chronic Chagas' Disease Cardiomyopathy Patients in Response to T. cruzi Ribosomal P Proteins
(Public Library of Science, 2014-06)
Background:Trypanosoma cruzi ribosomal P proteins, P2β and P0, induce high levels of antibodies in patients with chronic Chagas' disease Cardiomyopathy (CCC). It is well known that these antibodies alter the beating rate ...
Serum biomarkers for the prediction of hepatocellular carcinoma
(Multidisciplinary Digital Publishing Institute, 2021-04)
Hepatocellular carcinoma (HCC) is a leading cause of global cancer death. Major etiologies of HCC relate to chronic viral infections as well as metabolic conditions. The survival rate of people with HCC is very low and has ...