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The impact of climate change on the geographical distribution of two vectors of Chagas disease: implications for the force of infection
(The Royal Society, 2015-04-05)
Chagas disease, caused by the parasite Trypanosoma cruzi, is the most important vector-borne disease in Latin America. The vectors are insects belonging to the Triatominae (Hemiptera, Reduviidae), and are widely distributed ...
Chronic Chagas disease with cardiodigestive involvement and the TcVI infective form of Trypanosoma cruzi. A case report
(Elsevier Ireland, 2012-12)
We report a patient with megacolon associated with TcVI infective lineage form of Trypanosoma cruzi. Although this megacolon was considered idiopathic, Chagas disease was suspected and diagnosed because of the concomitant ...
Chagas disease vector control and Taylor's law
(Public Library of Science, 2017-11)
Background: Large spatial and temporal fluctuations in the population density of living organisms have profound consequences for biodiversity conservation, food production, pest control and disease control, especially ...
Insights from quantitative and mathematical modelling on the proposed WHO 2030 goals for Chagas disease
(Bill and Melinda Gates Foundation, 2019-12)
Chagas disease (CD) persists as one of the neglected tropical diseases (NTDs) with a particularly large impact in the Americas. The World Health Organization (WHO) recently proposed goals for CD elimination as a public ...
Mixed infections by different Trypanosoma cruzi discrete typing units among Chagas disease patients in an endemic community in Panama
(Public Library of Science, 2020-11-12)
Background Trypanosoma cruzi, the hemoparasite that causes Chagas disease, is divided into six Discrete Typing Units or DTUs: TcI-TcVI plus Tcbat. This genetic diversity is based on ecobiological and clinical characteristics ...
In silico drug repositioning for chagas disease
(Bentham Science Publishers, 2020)
Chagas disease is an infectious tropical disease included within the group of neglected tropical diseases. Though historically endemic to Latin America, it has lately spread to high-income countries due to human migration. ...
What are we talking about when we talk about education and Chagas? A systematic review of the issue
(Elsevier Science, 2020-05-01)
More than 110 years has passed since the first publications on Chagas disease, and it still urges the necessity of understanding it as a complex socioenvironmental issue in which components of diverse nature converge and ...
Honokiol attenuates oxidative stress-dependent heart dysfunction in chronic Chagas disease by targeting AMPK / NFE2L2 / SIRT3 signaling pathway
(Elsevier Science Inc., 2020-08)
Chronic cardiomyopathyis the most serious and frequent manifestation of Chagas disease caused by Trypanosoma cruzi. Free radicals are acrucial factor in Chagas pathogenesis. Parasite infection of cardiomyocytesexacerbates ...
Antiprotozoal QSAR modelling for trypanosomiasis (Chagas disease) based on thiosemicarbazone and thiazole derivatives
(Elsevier Science Inc., 2021-03)
Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, remains a neglected endemic infection that affects around 8 million people worldwide and causes 12,000 premature deaths per year. Traditional chemotherapy ...
Impaired frequencies and function of platelets and tissue remodeling in chronic Chagas disease
(Public Library of Science, 2019-06)
Chronic inflammation, as a consequence of the persistent infection with Trypanosoma cruzi, leads to continuous activation of the immune system in patients with chronic Chagas disease. We have previously shown that increased ...