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Perinatal protein malnutrition alters expression of miRNA biogenesis genes Xpo5 and Ago2 in mice brain
(Elsevier Ireland, 2017-04)
Due to its widespread incidence, maternal malnutrition remains one of the major non-genetic factors affecting the development of newborn's brain. While all nutrients have certain influence on brain maturation, proteins ...
Demyelination-remyelination in the CNS: ligand-dependent participation of the Notch signaling pathway
(Oxford University Press, 2019-06)
Multiple sclerosis (MS) is an immune-mediated central nervous system disease mostly affecting young people. Multiple sclerosis and other neurodegenerative and white matter disorders involve oligodendrocyte (OL) damage and ...
Light pollution: The possible consequences of excessive illumination on retina
(Nature Publishing Group, 2016-02)
Light is the visible part of the electromagnetic radiation within a range of 380-780 nm; (400-700 on primates retina). In vertebrates, the retina is adapted to capturing light photons and transmitting this information to ...
Editorial: Glial cells, maladaptive plasticity, and neurodegeneration: Mechanisms, targeted therapies, and future directions
(Frontiers Media S.A., 2021-04-30)
Understanding the biological complexity of the central nervous system (CNS) is a frontier in neuroscience. Morphological organization of the CNS represents the basis for its functional properties underlying higher brain ...
Priming Astrocytes With HIV-Induced Reactive Oxygen Species Enhances Their Trypanosoma cruzi Infection
(Frontiers Media S.A., 2020-10)
Introduction: Trypanosoma cruzi is an intracellular protozoa and etiological agent that causes Chagas disease. Its presence among the immunocompromised HIV-infected individuals is relevant worldwide because of its impact ...
Intergenerational transmission of maternal care deficiency and offspring development delay induced by perinatal protein malnutrition
(Taylor & Francis, 2018-08)
Objectives: Early life represents a sensitive and critical period for an individual. Nutrition plays a crucial role in the maturation and functional development of the central nervous system. Inadequate nutrition before ...
Interleukin-6: A cytokine to forget
(Federation of American Societies for Experimental Biology, 2004-09)
It is known that proinflammatory cytokines such as interleukin-6 (IL-6) are expressed in the central nervous system (CNS) during disease conditions and affect several brain functions including memory and learning. In ...
Negative modulation of the GABAAρ1 receptor function by l-cysteine
(Wiley Blackwell Publishing, Inc, 2018-01)
l-Cysteine is an endogenous sulfur-containing amino acid with multiple and varied roles in the central nervous system, including neuroprotection and the maintenance of the redox balance. However, it was also suggested as ...
Understanding the glioblastoma tumor biology to optimize photodynamic therapy: From molecular to cellular events
(Wiley-liss, div John Wiley & Sons Inc., 2020-12)
Photodynamic therapy (PDT) has recently gained attention as an alternative treatment of malignant gliomas. Glioblastoma (GBM) is the most prevalent within tumors of the central nervous system (CNS). Conventional treatments ...
Maternally inherited Leigh syndrome detected by Multiplex ligation-dependent probe amplification
(Taylor & Francis Ltd, 2019-01-12)
Leigh syndrome (LS) is a mitochondrial progressive encephalopathy characterized by bilateral symmetric necrotic lesions of the central nervous system. Maternally inherited Leigh Syndrome (MILS) represents 10–20% of LS. ...