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Mostrando ítems 251-259 de 259
Antimicrobial activity of myotoxic phospholipases A2 from crotalid snake venoms and synthetic peptide variants derived from their C-terminal region
(2005)
A short peptide derived from the C-terminal region of Bothrops asper myotoxin II, a Lys49 phospholipase A2 (PLA2), was
previously found to reproduce the bactericidal activity of its parent molecule. In this study, a panel ...
Calcium ion independent membrane leakage induced by phospholipase-like myotoxins
(1992-12)
The two snake venom myotoxins ammodytin L and myotoxin II, purified respectively from Vipera ammodytes ammodytes and Bothrops asper, have phospholipase-like structures but lack an Asp-49 in the active site and are without ...
Clinical and laboratory alterations in horses during immunization with snake venoms for the production of polyvalent (Crotalinae) antivenom
(1997-01)
Six horses were immunized with the venoms of Bothrops asper, Crotalus durissus durissus and Lachesis muta stenophrys for the production of polyvalent (Crotalinae) antivenom. During the immunization, clinical and laboratory ...
Lys-49 phospholipases A2 as active enzymes for beta-arachidonoyl phospholipid bilayer membranes
(1997)
Phospholipases A2 containing Lys-49 have been reported to be extremely weak or
inactive as enzyme. We have recently shown that basic proteins I and II (BP-I and BP-II), Lys-
49-PLA2s isolated from the venom of Trimeresurus ...
Differential susceptibility of C2C12 myoblasts and myotubes to group II phospholipase A2 myotoxins from crotalid snake venoms
(2005)
Group II phospholipase A2 (PLA2) myotoxins isolated from Viperidae/Crotalidae snake venoms induce a rapid cytolytic
effect upon diverse cell types in vitro. Previous studies suggested that this effect could be more ...
Neutralizing properties of Varespladib toward group I and II myotoxic phospholipases A2
(2019)
A need exists to develop specific and clinically useful inhibitors of toxic enzymes present in snake venoms,
responsible for severe tissue damage and life-threatening effects occurring in thousands of people suffering
...
Autocatalytic acylation of phospholipase-like myotoxins
(1995-04)
Several snake venoms contain a phospholipase A2 in which position 49 in the active site is occupied by a lysine or a serine instead of the aspartate residue normally found. Although these proteins do not bind Ca2+ and are ...
Snake venom components enhance pain upon subcutaneous injection: an initial examination of spinal cord mediators
(2004-09)
Snakebites are a relevant public health problem in Central and South America. Snake bite envenomations cause intense pain, not relieved by anti-venom. The fangs of many species are short, causing subcutaneous injection. ...
Venom of the crotaline snake Atropoides nummifer (jumping viper) from Guatemala and Honduras: comparative toxicological characterization, isolation of a myotoxic phospholipase A(2) homologue and neutralization by two antivenoms
(2001-07)
A comparative study was performed on the venoms of the crotaline snake Atropoides nummifer from Guatemala and Honduras. SDS-polyacrylamide gel electrophoresis, under reducing conditions, revealed a highly similar pattern ...