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Solar UV-B influences microfaunal community composition in a Tierra del Fuego peatland
(Pergamon-Elsevier Science Ltd, 2005-12)
The peatlands of Tierra del Fuego are subject to increased solar ultraviolet-B radiation (UV-B) due to the influence of the Antarctic "ozone hole". Research into the effects of climate change and ozone depletion on peatlands ...
Seasonal changes in morphophysiological traits of two native Patagonian shrubs from Argentina with different drought resistance strategies
(Elsevier Masson, 2018-06)
In semi-arid regions, plants develop various biochemical and physiological strategies to adapt to dry periods. Understanding the resistance mechanisms to dry periods under field conditions is an important topic in ecology. ...
(-)-Epicatechin prevents TNFα-induced activation of signaling cascades involved in inflammation and insulin sensitivity in 3T3-L1 adipocytes
(Elsevier Science Inc, 2012-11)
Obesity is major public health concern worldwide and obese individuals exhibit a higher risk of chronic diseases such as type 2 diabetes. Inflammation plays a significant role in metabolic regulation and mounting evidence ...
Activation of β 3 adrenergic receptor decreases DNA synthesis in human skin fibroblasts via cyclic GMP/nitric oxide pathway
(Karger, 2005-07)
Background: Evidences have shown that β 1 and β 2 adrenoceptors co-exist in human fibroblasts, but it is not yet clear the functional expression of β 3 adrenoceptor in these cells. The aim of this study was to investigate ...
Exploring the role of residue 228 in substrate and inhibitor recognition by VIM Metallo-β-lactamases
(American Chemical Society, 2015-05)
β-Lactamase inhibitors (BLIs) restore the efficacy of otherwise obsolete β-lactams. However, commercially available BLIs are not effective against metallo-β-lactamases (MBLs), which continue to be disseminated globally. ...
Volatile anaesthetics induce biochemical alterations in the heme pathway in a B-lymphocyte cell line established from hepatoerythropoietic porphyria patients (LBHEP) and in mice inoculated with LBHEP cells
(Pergamon-Elsevier Science Ltd, 2004-02)
Hepatoerythropoietic porphyria (HEP) is the homozygous form of Porphyria Cutanea Tarda (PCT), characterized by an accumulation of porphyrins due to uroporphyrinogen decarboxylase deficiency. Fluorinated volatile anaesthetics ...
Effects of dietary omega-3 PUFAs on growth and development: Somatic, neurobiological and reproductive functions in a murine model
(Elsevier Science Inc, 2018-11)
Omega-3 polyunsaturated fatty acids (ω-3 PUFAs) are relevant to fetal and infant growth and development. Objective: to assess whether long-term exposure to dietary ω-3 PUFA imbalance alters pre- and/or postnatal pups' ...
Fluorinated oxysterol analogues: Synthesis, molecular modelling and LXRβ activity
(Pergamon-Elsevier Science Ltd, 2017-01)
Liver X receptors (LXRs) are nuclear receptors that play central roles in the transcriptional control of lipid metabolism. The ability of LXRs to integrate metabolic and inflammation signalling makes them attractive targets ...
2-iodohexadecanal Inhibits thyroid cell growth in part through the induction of let-7f microRNA
(Elsevier Ireland, 2015)