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Activation of zebrafish Src family kinases by the prion protein is an amyloid-beta-sensitive signal that prevents the endocytosis and degradation of
(Springer, 2016)
BACKGROUND: Prions and amyloid-beta (Abeta) oligomers trigger neurodegeneration by hijacking a poorly understood cellular signal mediated by the prion protein (PrP) at the plasma membrane. In early zebrafish embryos, ...
Retinoic acid reduces migration of human breast cancer cells: role of retinoic acid receptor beta
(Wiley, 2014-01)
Breast cancer is the most common malignancy in women and the appearance of distant metastases produces the death in 98% of cases. The retinoic acid receptor b (RARb) is not expressed in 50% of invasive breast carcinoma ...
Beta-cell function and insulin resistance among Peruvian adolescents with type 2 diabetes
(Elsevier, 2016)
OBJECTIVE: To characterize and compare the beta-cell function and insulin resistance among Peruvian adolescents with type 2 diabetes (T2D) and their non-diabetic, overweight and lean peers. METHODS: Cross-sectional study ...
Downregulation of beta adrenergic receptor expression on B cells by activation of early signals in alloantigen-induced immune response
(Karger, 2000-12)
Previously we described a decrease in β-adrenergic receptor expression in B lymphocytes as a consequence of in vivo alloimmunization. This decrease correlates with the highest response of alloantibody production by B cells. ...
Therapeutics utilizing cell-based interventions for type 1 diabetes mellitus
(Wiley, 2013-02)
Type 1 diabetes mellitus (T1DM) results from death of insulin-secreting β cells mediated by self-immune cells, and the consequent inability of the body to maintain insulin levels for appropriate glucose homeostasis. Probably ...
Extended-spectrum beta-lactamase-producing Enterobacteriaceae in cell phones of health care workers from Peruvian pediatric and neonatal intensive care units
(Elsevier, 2016)
BACKGROUND: Health care workers (HCWs) use their mobile phones during working hours or medical care. There is evidence that the instruments are colonized with pathogenic microorganisms. Here, we describe levels of ...
Beta cell adaptation/dysfunction in an animal model of dyslipidemia and insulin resistance induced by the chronic administration of a sucrose-rich diet
(Landes Bioscience Journal, 2010-11)
Glucose stimulated insulin secretion (GSIS) was different in rats chronically fed a sucrose-rich diet (SRD) for 3 or 30 wk. This work proposes possible mechanisms underlying insulin secretion changes from â-cell throughout ...
Perinatal DEHP exposure modulates pituitary estrogen receptor α and β expression altering lactotroph and somatotroph cell growth in prepuberal and adult male rats
(Pergamon-Elsevier Science Ltd, 2021-12)
Phthalates are synthetic chemicals widely used to make polyvinylchloride (PVC) soft and flexible. Of these, Di-(2-ethylhexyl) phthalate (DEHP) is the most commonly used, with high human exposure occurring as early as the ...