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Light in the transcription landscape: chromatin, RNA polymerase II and splicing throughout Arabidopsis thaliana's life cycle
(Taylor & Francis, 2020-08)
Plants have a high level of developmental plasticity that allows them to respond and adapt to changes in the environment. Among the environmental cues, light controls almost every aspect of A. thaliana’s life cycle, including ...
Innovative Therapeutic and Delivery Approaches Using Nanotechnology to Correct Splicing Defects Underlying Disease
(Frontiers Media, 2020-07)
Alternative splicing of pre-mRNA contributes strongly to the diversity of cell- and tissue-specific protein expression patterns. Global transcriptome analyses have suggested that >90% of human multiexon genes are alternatively ...
Nuclear matrix protein Matrin 3 regulates alterna tive splicing and forms overlapping regulatory networks with PTB
(Nature Publishing Group, 2015-01)
Matrin3 is an RNA‐ and DNA‐binding nuclear matrix protein found to be associated with neural and muscular degenerative diseases. A number of possible functions of Matrin3 have been suggested, but no widespread role in RNA ...
How Slow RNA Polymerase II Elongation Favors Alternative Exon Skipping
(Cell Press, 2014-05)
Splicing is functionally coupled to transcription, linking the rate of RNA polymerase II (Pol II) elongation and the ability of splicing factors to recognize splice sites (ss) of various strengths. In most cases, slow Pol ...
Involvement of hnRNP A1 in the matrix metalloprotease-3-dependent regulation of Rac1 pre-mRNA splicing
(Wiley-liss, Div John Wiley & Sons Inc, 2012-07)
Rac1b is an alternatively spliced isoform of the small GTPase Rac1 that includes the 57-nucleotide exon 3b. Rac1b was originally identified through its over-expression in breast and colorectal cancer cells, and has ...
Alternative AKT2 splicing produces protein lacking the hydrophobic motif regulatory region
(Public Library of Science, 2020-11)
Three AKT serine/threonine kinase isoforms (AKT1/AKT2/AKT3) mediate proliferation, metabolism, differentiation and anti-apoptotic signals. AKT isoforms are activated downstream of PI3-kinase and also by PI3-kinase independent ...
The Arabidopsis lncRNA ASCO modulates the transcriptome through interaction with splicing factors
(Nature Publishing Group, 2020-04)
Alternative splicing (AS) is a major source of transcriptome diversity. Long noncoding RNAs (lncRNAs) have emerged as regulators of AS through different molecular mechanisms. In Arabidopsis thaliana, the AS regulators NSRs ...
A chloroplast retrograde signal regulates nuclear alternative splicing
(American Association For The Advancement Of Science, 2014-04)
Light is a source of energy and also a regulator of plant physiological adaptations. We show here that light/dark conditions affect alternative splicing of a subset of Arabidopsis genes preferentially encoding proteins ...
Transcriptional control of alternative splicing along time: Ideas change, experiments remain
(Cold Spring Harbor Laboratory Press, 2015-04)
Evidence on the co-transcriptionality of splicing and on a role for the transcription machinery on splice site selection started to be published before the launching of RNA. However, it was during the last 20 years that ...
Nonsense-Associated Alternative Splicing of the Human Thyroglobulin Gene
(Springer, 2012-12-01)
Introduction: We have described in previous articles a nonsense mutation (4588C>T, R1511X) in exon 22 of the thyroglobulin (TG) gene in a member of a family with a complex history of congenital goiter. In the mutated thyroid ...