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Innate-immunity cytokines induced by very small size proteoliposomes, a Neisseria-derived immunological adjuvant
(Wiley Blackwell Publishing, Inc, 2007-02)
Neisserial outer membrane proteins have been combined with monosialoganglioside GM3 to form very small size proteoliposomes (VSSP), a nanoparticulated formulation used as a cancer vaccine for the treatment of cancer patients ...
Immune response of heifers against a Staphylococcus aureus CP5 whole cell and lysate vaccine formulated with ISCOM Matrix adjuvant
(2014-02)
Staphylococcus aureus is the most frequently isolated pathogen from bovine intramammary infections worldwide. Commercially available vaccines for mastitis control are composed either of S. aureus lysates or whole-cells ...
Systemic administration of imiquimod as an adjuvant improves immunogenicity of a tumor-lysate vaccine inducing the rejection of a highly aggressive T-cell lymphoma
(Elsevier, 2019-06)
T-cell lymphomas include diverse malignancies. They are rare, some have low survival rates and they lack curative therapies. The aim of this work was to assess whether employing the TLR7 agonist imiquimod and the T-cell ...
Humoral immune response of pregnant goats to two Corynebacterium pseudotuberculosis bacterin formulations
(Universidad Austral de Chile, 2018-01)
Caseous lymphadenitis is a chronic suppurative bacterial disease caused by Corynebacterium pseudotuberculosis with a high prevalence in small ruminants. Different vaccine preparations have been employed to control this ...
An update of cutaneous melanoma patients treated in adjuvancy with the allogeneic melanoma vaccine vaccimel and presentation of a selected case report with in-transit metastases
(Frontiers Media, 2022-04)
The CSF-470 vaccine (VACCIMEL) plus BCG and GM-CSF as adjuvants has been assayed in cutaneous melanoma patients. In the adjuvant randomized Phase II study CASVAC-0401, vaccinated patients had longer distant metastasis-free ...
A New Cage-Like Particle Adjuvant Enhances Protection of Foot-and-Mouth Disease Vaccine
(Frontiers Media, 2020-07)
Foot-and-Mouth Disease (FMD) is an acute viral disease that causes important economy losses. Vaccines with new low-cost adjuvants that stimulate protective immune responses are needed and can be assayed in a mouse model ...
IMT504: A New and Potent Adjuvant for Rabies Vaccines Permitting Significant Dose Sparing
(Scientific Research Publishing Inc, 2012-11)
Background: Rabies virus infection causes encephalitis, which is almost always fatal. Vaccination can be extremely effective at preventing disease but is prohibitively costly. Vaccine formulations allowing dose-sparing and ...
Antibody response to a viral transcriptional regulator.
(Elsevier Science, 2003-12)
The E2 transcriptional activator of the human papillomavirus regulates the expression of most viral transcripts. Its binding to specific target DNA sequences involves large conformational changes in the interacting ...
Genetic engineering of Lactococcus lactis co-producing antigen and the mucosal adjuvant 3' 5'- cyclic di Adenosine Monophosphate (c-di-AMP) as a design strategy to develop a mucosal vaccine prototype
(Frontiers Research Foundation, 2018-09)
Lactococcus lactis is a promising candidate for the development of mucosal vaccines. More than 20 years of experimental research supports this immunization approach. In addition, 3' 5'- cyclic di-adenosine monophosphate ...
Adjuvant activity of CpG-ODN formulated as a liquid crystal
(Elsevier, 2013)