Buscar
Mostrando ítems 1-10 de 408
Vaccination-induced skin-resident memory CD8(+) T cells mediate strong protection against cutaneous melanoma
(Taylor & Francis, 2018)
Memory CD8(+) T cell responses have the potential to mediate long-lasting protection against cancers. Resident memory CD8(+) T (Trm) cells stably reside in non-lymphoid tissues and mediate superior innate and adaptive ...
Pulsing Dendritic Cells with Whole Tumor Cell Lysates
(Springer, 2014-03)
One of the strategies employed in immunotherapy for cancer is to use of ex vivo-generated dendritic cells (DC) pulsed with tumor antigens. Several approaches have been used to obtain and load tumor antigens in DC. One such ...
Natural killer cells as helper cells in dendritic cell cancer vaccines
(Frontiers Research Foundation, 2015-01)
Vaccine-based cancer immunotherapy has generated highly variable clinical results due to differing methods of vaccine preparation and variation in patient populations among other lesser factors. Moreover, these clinical ...
Tumor cell lysates as immunogenic sources for cancer vaccine design
(2014)
Autologous dendritic cells (DCs) loaded with tumor-associated antigens (TAAs) are a promising immunological tool for cancer therapy. These stimulate the antitumor response and immunological memory generation. Nevertheless, ...
Tumor cell lysates as immunogenic sources for cancer vaccine design
(Landes Bioscience, 2014)
© 2014 Taylor & Francis Group, LLC Autologous dendritic cells (DCs) loaded with tumor-associated antigens (TAAs) are a promising immunological tool for cancer therapy. These stimulate the antitumor response and immunological ...
Ex Vivo Loading of Autologous Dendritic Cells with Tumor Antigens
(Springer, 2014-02)
Ex vivo-generated antigen-loaded dendritic cells (DC) have been shown to be immunogenic in patients with cancer. Loading DC with autologous whole tumor antigens is a strategy to arm DC against tumor without human leukocyte ...
Tumor-Specific CD8+ T-Cell Responses Induced by DNA Vaccination
(Humana Press Inc., 2021)
DNA vaccines assisted by electroporation efficiently trigger antitumor cytotoxic CD8+ T cell responses in preclinical cancer models and hold potential for human use. They can be easily engineered to express either ...
Evaluation of T-Cell Responses Against Shared Melanoma Associated Antigens and Predicted Neoantigens in Cutaneous Melanoma Patients Treated With the CSF-470 Allogeneic Cell Vaccine Plus BCG and GM-CSF
(Frontiers Media S.A., 2020-06)
The CSF-470 vaccine consists of lethally-irradiated allogeneic cells derived from four cutaneous melanoma cell lines administered plus BCG and GM-CSF as adjuvants. In an adjuvant phase II study vs. IFN-α2b, the vaccine ...