Artículo de revista
Vaccination-induced skin-resident memory CD8(+) T cells mediate strong protection against cutaneous melanoma
Fecha
2018Registro en:
Oncoimmunology 2018, Vol. 7, No. 7, e1442163
2162-402X
10.1080/2162402X.2018.1442163
Autor
Gálvez Cancino, Felipe
López, Ernesto
Menares, Evelyn
Díaz, Ximena
Zapata Flores, Camila
Cáceres, Pablo
Hidalgo, Sofía
Chovar, Ornella
Alcántara Hernández, Marcela
Borgna, Vicenzo
Varas Godoy, Manuel
Salazar Onfray, Flavio
Idoyaga, Juliana
Lladser, Álvaro
Institución
Resumen
Memory CD8(+) T cell responses have the potential to mediate long-lasting protection against cancers. Resident memory CD8(+) T (Trm) cells stably reside in non-lymphoid tissues and mediate superior innate and adaptive immunity against pathogens. Emerging evidence indicates that Trm cells develop in human solid cancers and play a key role in controlling tumor growth. However, the specific contribution of Trm cells to anti-tumor immunity is incompletely understood. Moreover, clinically applicable vaccination strategies that efficiently establish Trm cell responses remain largely unexplored and are expected to strongly protect against tumors. Here we demonstrated that a single intradermal administration of gene- or protein-based vaccines efficiently induces specific Trm cell responses against models of tumor-specific and self-antigens, which accumulated in vaccinated and distant non-vaccinated skin. Vaccination-induced Trm cells were largely resistant to in vivo intravascular staining and antibody-dependent depletion. Intradermal, but not intraperitoneal vaccination, generated memory precursors expressing skin-homing molecules in circulation and Trm cells in skin. Interestingly, vaccination-induced Trm cell responses strongly suppressed the growth of B16F10 melanoma, independently of circulating memory CD8(+) T cells, and were able to infiltrate tumors. This work highlights the therapeutic potential of vaccination-induced Trm cell responses to achieve potent protection against skin malignancies
Ítems relacionados
Mostrando ítems relacionados por Título, autor o materia.
-
Interference of vaccinal antibodies on serological diagnosis of leptospirosis in vaccinated buffalo using two types of commercial vaccines
Nardi Júnior, Geraldo de; Genovez, Margareth Elide; Ribeiro, Márcio Garcia; Castro, Vanessa; Jorge, Andre Mendes -
Method For Constructing An Attenuated Mutant Strain Of Pathogenic Bacteria, Vaccine, Vaccine Vector And Use Of Said Vaccine
Brocchi Marcelo; Pivetta Luciane Benedita Duarte -
Method For Constructing An Attenuated Mutant Strain Of Pathogenic Bacteria, Vaccine, Vaccine Vector And Use Of Said Vaccine
Brocchi Marcelo [br]; Pivetta Luciane Benedita Duarte [br]