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Evaluation of proline analogs as trypanocidal agents through the inhibition of a Trypanosoma cruzi proline transporter
(Elsevier Science, 2017-08)
Background: Trypanosoma cruzi, the etiological agent of Chagas disease, uses proline as its main carbon source, essential for parasite growth and stage differentiation in epimastigotes and amastigotes. Since proline is ...
Identification of Trypanosoma cruzi Polyamine Transport Inhibitors by Computational Drug Repurposing
(Frontiers Research Foundation, 2019-10)
Trypanosoma cruzi is the causative agent of Chagas disease, a parasitic infection endemic in Latin America. In T. cruzi the transport of polyamines is essential because this organism is unable to synthesize these compounds ...
Effects of Trypanocidal Treatment on Echocardiographic Parameters in Chagas Cardiomyopathy and Prognostic Value of Wall Motion Score Index: A BENEFIT Trial Echocardiographic Substudy
(Mosby-Elsevier, 2019-02)
Background: Serial echocardiographic studies in chronic Chagas cardiomyopathy are scarce. The aims of this study were to evaluate whether therapy with benznidazole modifies the progression of cardiac impairment and to ...
Synthesis and in vitro trypanocide activity of several polycyclic drimane-quinone derivativesBIOORGANIC & MEDICINAL CHEMISTRYBIOORG MED CHEM
(PERGAMON-ELSEVIER SCIENCE LTD, 2017)