Now showing items 1-10 of 27
Tricyclic antidepressants inhibit homomeric Cys-loop receptors by acting at different conformational states
(Elsevier Science, 2008-04)
Tricyclic antidepressants not only inhibit monoamine reuptake but also modulate Cys-loop receptors. However, it is not understood how this modulation is involved in their therapeutic effects. We analyzed the mechanisms of ...
Angular tricyclic benzofurans and related natural products of fungal origin. Isolation, biological activity and synthesis
(Royal Society of Chemistry, 2013-04)
Naturally-occurring angular tricyclic benzofuran derivatives of fungal origin and related compounds, in which two heterocyclic rings are fused to a central benzenoid moiety, are covered. Emphasis is placed on the structure ...
Mastering tricyclic ring systems for desirable functional cannabinoid activity
(Elsevier Masson, 2013-11)
There is growing interest in using cannabinoid receptor 2 (CB2) agonists for the treatment of neuropathic pain and other indications. In continuation of our ongoing program aiming for the development of new small molecule ...
Tricyclic antidepressants inhibit hippocampal α7* and α9α10 nicotinic acetylcholine receptors by different mechanisms
(Pergamon-Elsevier Science Ltd, 2018-07)
The activity of tricyclic antidepressants (TCAs) at α7 and α9α10 nicotinic acetylcholine receptors (AChRs) as well as at hippocampal α7-containing (i.e., α7*) AChRs is determined by using Ca 2+ influx and electrophysiological ...
Paesslerins A and B: novel tricyclic sesquiterpenoids from the soft coral Alcyonium paessleri
(American Chemical Society, 2001-05)
matrix presented In the course of our search of new bioactive metabolites from marine invertebrates, paesslerins A and B, sesquiterpenoids with an unprecedented tricyclic skeleton, were isolated from the subAntarctic soft ...
Synthesis of the unique angular tricyclic chromone structure proposed for aspergillitine, and its relationship with alkaloid TMC-120B
(Royal Society of Chemistry, 2012-03)
The synthesis of the tricyclic angular chromone structure originally assigned to aspergillitine is reported. The synthesis was achieved in 11 steps and 15% overall yield from 2,4-dihydroxypropiophenone, through the ...
A Convenient and Atom-Economic One-Pot Selenium-Chloride-Mediated Synthesis of 2-Arylselenopheno[2,3-b] indoles and Their Antifungal Activity
A facile and convenient atom‐economic protocol for the one‐pot synthesis of 2‐aryl selenopheno[2,3‐b]indoles, by an electrophilic cyclization of 3‐(arylalkynyl)indoles with SeCl2 prepared in situ as the selenium source, ...
A quantitative review on outcome-to-antidepressants in melancholic unipolar depression
(Elsevier Ireland, 2018-07)
The aim of this study was to explore outcome to antidepressants profile in melancholic unipolar depression. We conducted a systematic review of electronic databases and meta-analysis of randomized and nonrandomized trials ...
COMPOSITIONAL VARIABILITY IN BITUMENS FROM EOLIC SEDIMENTARY FACIES OF PIRAMBÓIA FORMATION, PARANÁ BASIN, BRAZIL: CHARACTERIZING BIODEGRADATION
(Sociedade Brasileira de Geoquímica, 2016)
A new antagonist of caenorhabditis elegans glutamate-activated chloride channels with anthelmintic activity
(Frontiers Media, 2020-08-19)
Nematode parasitosis causes significant mortality and morbidity in humans andconsiderable losses in livestock and domestic animals. The acquisition of resistanceto current anthelmintic drugs has prompted the search for new ...