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Two-dimensional transport analysis of transdermal drug absorption with a non-perfect sink boundary condition at the skin-capillary interface
(ELSEVIER SCIENCE INC, 2013-07-01)
A transient percutaneous drug absorption model was solved in two dimensions. Clearance of the topically-applied pharmaceutical occured at the skin-capillary boundary. Timolol penetration profiles in the dermal tissue were ...
The short-term effects of diammine silver fluoride on tooth sensitivity: A randomized controlled trial
(SAGE Publications, 2011)
Tooth sensitivity is a common clinical problem. This multi-center randomized clinical trial assessed the effectiveness and safety of topical diammine silver fluoride. From two sites (Lima and Cusco, Peru), 126 adults with ...
Additional evidence to support the phasing-out of treatment category II regimen for pulmonary tuberculosis in Peru
(Oxford University Press, 2012)
The effectiveness of the World Health Organization's (WHO) treatment category II regimen for tuberculosis in 124 patients was compared to that of 1147 patients receiving treatment category I in Lima, Peru following WHO's ...
Ciprofloxacin-intercalated layered double hydroxide-in-hybrid films as composite dressings for controlled antimicrobial topical delivery
(Elsevier Science, 2020-06)
Films based on biopolymers and loaded with antimicrobial agents are convenient pharmaceutical dosage forms for topical application. Inorganic carriers loaded with these agents lead to composite materials, which combined ...
Solid Lipid Nanoparticles for Drug Delivery: Pharmacological and Biopharmaceutical Aspects
(Frontiers Media S.A., 2020-10-30)
In the golden age of pharmaceutical nanocarriers, we are witnessing a maturation stage of the original concepts and ideas. There is no doubt that nanoformulations are extremely valuable tools for drug delivery applications; ...
Efficacy of topical Miltefosine formulations in an experimental model of cutaneous leishmaniasis
(Springer, 2021-01-27)
Cutaneous leishmaniasis (CL) is a neglected tropical disease endemic in ~ 90 countries, with an increasing incidence. Presently available pharmacotherapy implies the systemic administration of moderately/very toxic drugs. ...
Nanoformulation for potential topical delivery of Vismodegib in skin cancer treatment
(Elsevier Science, 2019-06-30)
Vismodegib (Erivedge®, Genentech) is a first-in-class inhibitor of the hedgehog signaling pathway for the treatment of basal cell carcinoma (BCC). The treatment currently consists of the oral administration of Erivedge® ...
Pharmacokinetics and absorption of paromomycin and gentamicin from topical creams used to treat cutaneous leishmaniasis
(American Society for Microbiology, 2013)
This study evaluated the pharmacokinetics of topical creams containing 15% paromomycin (“paromomycin alone”) and 15% paromomycin plus 0.5% gentamicin (WR 279,396) in patients with cutaneous leishmaniasis. The investigational ...
Ciprofloxacin loaded o/w microemulsion against Staphylococcus aureus: Analytical and biological studies for topical and intranasal administration
(Elsevier Science, 2020-06)
An o/w microemulsion was designed and successfully loaded with the antibiotic ciprofloxacin for potentialtopical and intranasal use against Staphylococcus aureus. Based up on a physicochemical study an optimal systemcomposed ...
Pattern of ivermectin (sheep) and doramectin (cattle) residues in muscular tissue from various anatomical locations
(Taylor & Francis Ltd, 2008-04)
This trial reports comparative drug residual concentrations in muscular tissue obtained from various anatomical locations after subcutaneous administration of ivermectin (IVM) to sheep and topical treatment with doramectin ...