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Novel therapeutic targets for arenavirus hemorrhagic fevers
(Future Medicine, 2011-01)
Several members of the family Arenaviridae can cause severe hemorrhagic fevers in humans, representing a serious public health problem in endemic areas of Africa and South America. The Lassa virus is the most prevalent and ...
Mitochondrial-derived peptide humanin as therapeutic target in cancer and degenerative diseases
(Informa Healthcare, 2019-02)
Introduction: Mitochondrial-derived peptides (MDPs) are encoded within the mitochondrial genome. They signal within the cell or are released to act as autocrine/paracrine/endocrine cytoprotective factors playing a key role ...
MRP4/ABCC4 as a new therapeutic target: meta-analysis to determine cAMP binding sites as a tool for drug design
(Bentham Science Publishers, 2017-12)
MRP4 transports multiple endogenous and exogenous substances and is critical not only for detoxification but also in the homeostasis of several signaling molecules. Its dysregulation has been reported in numerous pathological ...
Signal Transduction Pathways as Therapeutic Target for Chagas Disease
(Bentham Science Publishers, 2019-06)
Trypanosomatids are a group of flagellated unicellular eukaryotes, which cause serious human diseases including Chagas disease (Trypanosoma cruzi), sleeping sickness (Trypanosoma brucei spp.) and Leishmaniasis (Leishmania ...
The transferrin receptor and the targeted delivery of therapeutic agents against cancer
(Elsevier Science, 2012-03)
Background: Traditional cancer therapy can be successful in destroying tumors, but can also cause dangerous side effects. Therefore, many targeted therapies are in development. The transferrin receptor (TfR) functions in ...
Entinostat (SNDX-275) for the treatment of non-small cell lung cancer
(Taylor and Francis, 2015)
INTRODUCTION: Epigenetic aberrations play an important role in lung carcinogenesis. Chromatin deacetylation is a fundamental mechanism of gene silencing. Histone deacetylase (HDAC) inhibitors are an emerging class of ...
Therapeutic targets to reduce the contribution of pulmonary neutrophilic inflammation towards obesity-associated co-morbidities: a mini-review
(Medwin Publishers, 2019-08)
Epidemiology and experimental models have shown a close link between adipose tissue inflammation, systemic inflammation and pulmonary neutrophilic inflammation, which predispose obese patients to pulmonary diseases, ...
Deep Learning to Therapeutically Target Unreported Complexes
(Elsevier Science London, 2019-05-21)
The disruption of large protein–protein (PP) interfaces remains a challenge in targeted therapy. Designing drugs that compete with binding partners is daunting, especially when the structure of the protein complex is ...
Pulmonary Neutrophilic Inflammation and Noncommunicable Diseases: Pathophysiology, Redox Mechanisms, Biomarkers, and Therapeutics
(Mary Ann Liebert, 2020-07)
Significance: Pulmonary neurophilic inflammation (PNI) is the homing and activation of neutrophil with damage to the microvasculature. This process is involved in pulmonary damage in patients exposed to airborne pollutants ...
Amino acid and polyamine membrane transporters in Trypanosoma cruzi: biological function and evaluation as drug targets
(Bentham Science Publishers, 2019-12)
Amino acids and polyamines are involved in relevant processes for the parasite Trypanosoma cruzi, like protein synthesis, stress resistance, life cycle progression, infection establishment and redox balance, among others. ...