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Designing improved active peptides for therapeutic approaches against infectious diseases
(Pergamon-Elsevier Science Ltd, 2018-03)
Infectious diseases are one of the main causes of human morbidity and mortality. In the last few decades, pathogenic microorganisms’ resistance to conventional drugs has been increasing, and it is now pinpointed as a major ...
New aspects of the interactions between the cardiovascular nitric oxide system and natriuretic peptides
(Academic Press Inc Elsevier Science, 2011-03)
Arterial blood pressure is regulated by a variety of endocrine, autocrine and neuronal systems. Natriuretic peptides and nitric oxide are important factors that exert synergistic vascular and cardiac actions and their ...
Mitochondrial-derived peptide humanin as therapeutic target in cancer and degenerative diseases
(Informa Healthcare, 2019-02)
Introduction: Mitochondrial-derived peptides (MDPs) are encoded within the mitochondrial genome. They signal within the cell or are released to act as autocrine/paracrine/endocrine cytoprotective factors playing a key role ...
Peptide Affinity Chromatography Applied to Therapeutic Antibodies Purification
(Springer, 2021-12)
The interest in therapeutic monoclonal antibodies (mAbs) has significantly grown in the pharmaceutical industry, exceeding 100 FDA mAbs approved. Although the upstream processing of their industrial production has been ...
Targeting tumors using peptides
(Multidisciplinary Digital Publishing Institute, 2020-02)
To penetrate solid tumors, low molecular weight (Mw < 10 KDa) compounds have an edge over antibodies: their higher penetration because of their small size. Because of the dense stroma and high interstitial fluid pressure ...
Immunomodulation induced by central nervous system-related peptides as a therapeutic strategy for neurodegenerative disorders
(John Wiley & Sons Inc., 2021-10)
Neurodegenerative diseases (NDD) are disorders characterized by the progressive loss of neurons affecting motor, sensory, and/or cognitive functions. The incidence of these diseases is increasing and has a great impact due ...
In vivo bactericidal efficacy of gwh1 antimicrobial peptide displayed on protein nanoparticles, a potential alternative to antibiotics
(MDPI AG, 2020-12)
Oligomerization of antimicrobial peptides into nanosized supramolecular complexes produced in biological systems (inclusion bodies and self-assembling nanoparticles) seems an appealing alternative to conventional antibiotics. ...
Synergistic and antibiofilm activity of the antimicrobial peptide P5 against carbapenem-resistant Pseudomonas aeruginosa
(Elsevier Science, 2019-07)
In the search for new antimicrobial molecules, antimicrobial peptides (AMPs) offer a viable alternative to conventional antibiotics, as they physically disrupt the bacterial membranes, leading to membrane disruption and ...
Searching for improved mimetic peptides inhibitors preventing conformational transition of amyloid-β 42 monomer
(Academic Press Inc Elsevier Science, 2018-12)
A series of novel mimetic peptides were designed, synthesised and biologically evaluated as inhibitors of Aβ 42 aggregation. One of the synthesised peptidic compounds, termed compound 7 modulated Aβ 42 aggregation as ...
Effect of trehalose on the interaction of Alzheimer's Aβ-peptide and anionic lipid monolayers
(Elsevier Science, 2011-01)
The interaction of amyloid β-peptide (Aβ) with cell membranes is believed to play a central role in the pathogenesis of Alzheimer's disease. In particular, recent experimental evidence indicates that bilayer and monolayer ...