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Exploring the role of antigen presenting cells in male genital tract
(Wiley Blackwell Publishing, Inc, 2018-12)
Antigen presenting cells (APCs) are a critical mediator between innate and adaptive immune response. APCs have diverse functions in physiological and pathological conditions, such as maintenance of tissue homoeostasis, ...
The role of regulatory T Cells in autoimmune orchitis
(Wiley Blackwell Publishing, Inc, 2018-12)
Regulatory T cells (Tregs) mediate tolerance to self-antigens maintaining immune homeostasis. Defects in the number and function of Tregs lead to aberrant immune responses to autologous components, thereby causing autoimmune ...
Pathomechanisms of autoimmune based testicular inflammation
(Frontiers Media, 2020-09)
Infection and inflammation of the male reproductive tract are relevant causes of infertility. Inflammatory damage occurs in the special immunosuppressive microenvironment of the testis, a hallmark termed testicular immune ...
Expression of co-stimulatory molecules, chemokine receptors and proinflammatory cytokines in dendritic cells from normal and chronically inflamed rat testis
(Oxford University Press, 2007-12)
The presentation of self antigens by dendritic cells (DC) plays an important role in the initiation and maintenance of autoimmunity. In a model of experimental autoimmune orchitis (EAO), we have previously characterized ...
Syngeneic B16-F1 cells are more efficient than allogeneic Cloudman cells as antigen source in DC-based vaccination in the B16-F1 murine melanoma model
(Elsevier, 2019-07)
A major obstacle to obtaining relevant results in cancer vaccination has been the lack of identification of immunogenic antigens. Dendritic cell (DC)-based cancer vaccines used preventively may afford protection against ...
Functional and phenotypical characteristics of testicular macrophages in experimental autoimmune orchitis
(John Wiley & Sons Ltd, 2008-01-22)
Testicular inflammation with compromised fertility can occur despite the fact that the testis is considered an immunoprivileged organ. Testicular macrophages have been described as cells with an immunosuppressor profile, ...
MAGE Proteins and the Regulation of E2F Pathway
(SciMed Central, 2017-04)
Melanoma Antigens Genes (MAGE) constitutes a mutagenic family divided in two subfamilies, MAGE-I and MAGE-II, according to its tissue pattern expression. While MAGE-I in adult humans are only expressed in testis and tumors ...
Perinatal exposure to Bisphenol A disturbs the early differentiation of male germ cells
(Pergamon-Elsevier Science Ltd, 2020-12)
Understanding the effects of Bisphenol A (BPA) on early germ cell differentiation and their consequences in adult life is an area of growing interest in the field of endocrine disruption. Herein, we investigate whether ...
Micro-encapsulated secretory leukocyte protease Inhibitor decreases cell-mediated immune response in autoimmune orchitis
(Pergamon-Elsevier Science Ltd, 2011-07)
AIMS: We previously reported that recombinant human Secretory Leukocyte Protease Inhibitor (SLPI) inhibits mitogen-induced proliferation of human peripheral blood mononuclear cells. To determine the relevance of this effect ...
Detection of viremia in the Porcine rubulavirus experimental infectionDetección de viremia en la infección experimental por Rubulavirus porcino
(Archivos de Medicina Veterinaria, 2004)