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Synaptic signals mediated by protons and acid sensing ion channels
(Veterinary and Human Toxicology, 2019-06)
Extracellular pH changes may constitute significant signals for neuronal communication. During synaptic transmission, changes in pH in the synaptic cleft take place. Its role in the regulation of presynaptic Ca2+ currents ...
Age-related alterations in mitochondrial physiological parameters and nitric oxide production in synaptic and non-synaptic brain cortex mitochondria
(Pergamon-Elsevier Science Ltd, 2011-08)
Brain aging has been associated with mitochondrial dysfunction and changes in nitric oxide levels. The aim of this study was to evaluate the susceptibility of synaptic and non-synaptic mitochondria to aging-dependent ...
Modulation of acid sensing ion channel dependent protonergic neurotransmission at the mouse calyx of Held
(Pergamon-Elsevier Science Ltd, 2020-07)
Acid-sensing ion channels (ASICs) regulate synaptic activities and play important roles in neurodegenerative diseases. It has been reported that homomeric ASIC-1a channels are expressed in neurons of the medial nucleus of ...
Editorial: Glial cells, maladaptive plasticity, and neurodegeneration: Mechanisms, targeted therapies, and future directions
(Frontiers Media S.A., 2021-04-30)
Understanding the biological complexity of the central nervous system (CNS) is a frontier in neuroscience. Morphological organization of the CNS represents the basis for its functional properties underlying higher brain ...
Iron-Induced Oxidative Injury Differentially Regulates PI3K/Akt/GSK3β Pathway in Synaptic Endings from Adult and Aged Rats
(Oxford University Press, 2009-10)
In this work we study the state of phosphoinositide-3-kinase/Akt/glycogen synthase kinase 3 beta (PI3K/Akt/GSK3 beta) signaling during oxidative injury triggered by free iron using cerebral cortex synaptic endings isolated ...
Graded boosting of synaptic signals by low-threshold voltage-activated calcium conductance
(American Physiological Society, 2015-05)
Low-threshold voltage-activated calcium conductances (LT-VACCs) play a substantial role in shaping the electrophysiological attributes of neurites. We have investigated how these conductances affect synaptic integration ...
Free radical production and antioxidant status in brain cortex non-synaptic mitochondria and synaptosomes at alcohol hangover onset
(Elsevier Science Inc, 2017-07)
Alcohol hangover (AH) is the pathophysiological state after a binge-like drinking. We have previously demonstrated that AH induced bioenergetics impairments in a total fresh mitochondrial fraction in brain cortex and ...
Acid-Sensing Ion Channels Activated by Evoked Released Protons Modulate Synaptic Transmission at the Mouse Calyx of Held Synapse
(Society for Neuroscience, 2017-03)
Acid-sensing ion channels (ASICs) regulate synaptic activities and play important roles in neurodegenerative diseases. We found that these channels can be activated in neurons of the medial nucleus of the trapezoid body ...
Brain cortex mitochondrial bioenergetics in synaptosomes and non-synaptic mitochondria during aging
(Springer/Plenum Publishers, 2016-01)
Alterations in mitochondrial bioenergetics have been associated with brain aging. In order to evaluate the susceptibility of brain cortex synaptosomes and non-synaptic mitochondria to aging-dependent dysfunction, male Swiss ...
Selective localization of phosphatidylcholine-derived signaling in detergent-resistant membranes from synaptic endings
(Elsevier Science, 2010-03)
Detergent-resistant membranes (DRMs) are a class of specialized microdomains that compartmentalize several signal transduction processes. In this work, DRMs were isolated from cerebral cortex synaptic endings (Syn) on the ...