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Highs and lows of sympathetic neurocardiovascular transduction: influence of altitude acclimatization and adaptation
(American Physiological Society, 2020)
High-altitude (>2,500 m) exposure results in increased muscle sympathetic nervous activity (MSNA) in acclimatizing lowlanders. However, little is known about how altitude affects MSNA in indigenous high-altitude populations. ...
Global Reach 2018: sympathetic neural and hemodynamic responses to submaximal exercise in Andeans with and without chronic mountain sickness
(American Physiological Society, 2022)
Andeans with chronic mountain sickness (CMS) and polycythemia have similar maximal oxygen uptakes to healthy Andeans. Therefore, this study aimed to explore potential adaptations in convective oxygen transport, with a ...
Global REACH 2018: Andean highlanders, chronic mountain sickness and the integrative regulation of resting blood pressure
(Wiley, 2020)
NEW FINDINGS: What is the central question of this study? Does chronic mountain sickness (CMS) alter sympathetic neural control and arterial baroreflex regulation of blood pressure in Andean (Quechua) highlanders? What ...
Global REACH 2018: the adaptive phenotype to life with chronic mountain sickness and polycythaemia
(Wiley, 2021)
Key points: Humans suffering from polycythaemia undergo multiple circulatory adaptations including changes in blood rheology and structural and functional vascular adaptations to maintain normal blood pressure and vascular ...
The sympathetic nervous system affects the susceptibility and course of Trypanosoma cruzi infection
(Academic Press Inc Elsevier Science, 2016-11)
Trypanosoma cruzi (T. cruzi) is an intracellular parasite that causes Chagas’ disease, a major health problem in Latin America. Using a murine model of infection with this parasite, we have previously shown that corticosterone ...
The sympathetic nervous system regulates skeletal muscle motor innervation and acetylcholine receptor stability
(Wiley Blackwell Publishing, Inc, 2019-03)
Aim: Symptoms of autonomic failure are frequently the presentation of advanced age and neurodegenerative diseases that impair adaptation to common physiologic stressors. The aim of this work was to examine the interaction ...
Antagonistic and Synergistic Activation of Cardiovascular Vagal and Sympathetic Motor Outflows in Trigeminal Reflexes
(Frontiers Research Foundation, 2017-02)
The trigeminal nerve and heart are strongly related through somato-autonomic nervous reflexes that induce rapid changes in cardiovascular function. Several trigeminal reflexes have been described, but the diving and ...
Free fatty acid receptor 3 is a key target of short chain fatty acid. What is the impact on the sympathetic nervous system?
(Landes Bioscience, 2014-04)
Nervous system (NS) activity participates in metabolic homeostasis by detecting peripheral signal molecules derived from food intake and energy balance. High quality diets are thought to include fiber-rich foods like whole ...
Depression promotes prostate cancer invasion and metastasis via a sympathetic-cAMP-FAK signaling pathway
(Nature Publishing Group, 2018-03)
Depression drives cancer progression and induces poor clinical outcome. However, the mechanisms underlying depression and cancer outcomes are unclear. In this work, we investigated 98 prostate cancer patients and found ...