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Alkylating Agents and Mouse Spermatogenesis: Effects of a Single Dose of Cyclophosphamide
(1985)
Summary: Cyclophosphamide (CFA) is one of the alkylating agents which has now been used with some success in the treatment of human neoplasias and renal disease. To evaluate how this drug could affect the seminiferous ...
Differential localization of α' and β subunits of protein kinase CK2 during rat spermatogenesis
(2009)
Protein kinase CK2 is a serine/threonine kinase expressed in organisms from yeast to human and is composed of a catalytic subunit (α or α') and a regulatory subunit (β) forming a holoenzyme with the possible subunit ...
Microtubule configuration and its relationship to sperm morphology in mammalian spermiogenesis
(2008)
The acrosome is a secretory vesicle located in the mammalian sperm head. Its main function is to transport hydrolytic enzymes. These enzymes will dissolve the zona pellucid, assisting the sperm in fertilizing the egg. The ...
Apoptosis, necrosis and autophagy are influenced by metabolic energy sources in cultured rat spermatocytes
(2012)
Apoptosis, necrosis and autophagy are mechanistically related processes that control tissue homeostasis and cell survival. In the testis, germ cell death is important for controlling sperm output, but it is unknown whether ...
Intracellular pH regulation in rat round spermatids
(Wiley-Blackwell Publishing Ltd, 1997)
Intracellular pH has been shown to be an important physiological parameter in cell cycle control and differentiation, aspects that are central to the spermatogenic process. However, the pH regulatory mechanisms in spermatogenic ...
Effect of intermittent hypoxia on the reproduction of rats exposed to high altitude in the Chilean Altiplano
(2009)
Cikutovic, Marcos, Nelson Fuentes, and Eduardo Bustos-Obregón. Effect of intermittent hypoxia on the reproduction of rats exposed to high altitude in the Chilean Altiplano. High Alt. Med. Biol. 10:357-363, 2009.- Environmental ...
Intracellular Ca2+ homeostasis in rat round spermatids
(Elsevier, 1998)
Intracellular calcium, [Caz+], can regulate meiotic progression of mammalian oocytes. However,
the role of [Ca2+], in the regulation of the spermatogenic process and its cellular homeostatic mechanisms
in spermatogenic ...
Effect of a single dose of malathion on spermatogenesis in mice
(2003)
Aim: To observe the acute effect of the organophosphorous insecticide malathion on testicular function in mice. Methods: The effects of a single dose of malathion [240 mg/kg (1/12 LD 50)] on plasma acetylcholinesterase ...
Expression and behaviour of CENP-E at kinetochores during mouse spermatogenesis
(2002)
Centromere protein E (CENP-E) is a microtubule motor protein localised in the outer kinetochore plate and in the fibrous corona that relocalises to the midzone in early anaphase. While its expression in somatic cells has ...
Involvement of TACE/ADAM17 and ADAM10 in etoposide-induced apoptosis of germ cells in rat spermatogenesis
(WILEY-BLACKWELL, 2012-02)
Germ cell apoptosis is important to regulate sperm production in the mammalian testis, but the molecular mechanisms underlying apoptosis are still poorly understood. We have recently shown that in vitro, etoposide induces ...